Determination of cepharanthine in rat plasma by LC–MS/MS and its application to a pharmacokinetic study

Y Deng, W Wu, S Ye, W Wang, Z Wang - Pharmaceutical biology, 2017 - Taylor & Francis
Context: Cepharanthine (CPA) has been reported to possess a wide range of
pharmacological activities. Objective: This study investigates the pharmacokinetic …

Bioanalysis of cepharanthine by LC–ESI–MS–MS and its application to pharmacokinetic studies

RH Dong, ZZ Fang, HZ Gao, GT Hao, G Liu, TT Shan… - Chromatographia, 2011 - Springer
A sensitive liquid chromatography–electrospray ionization–tandem mass spectrometry (LC–
ESI–MS–MS) method was developed and validated for the quantification of cepharanthine …

Simple, sensitive and rapid HPLC–MS/MS method for the determination of cepharanthine in human plasma

G Hao, H Liang, Y Li, H Li, H Gao, G Liu… - Journal of Chromatography …, 2010 - Elsevier
A rapid, sensitive and specific method for the determination of cepharanthine in human
plasma using high performance liquid chromatography coupled with tandem mass …

Rapid and simple method for determination of cephradine in human plasma using liquid chromatography–tandem mass spectrometry (LC–MS/MS): Application to the …

SJ Choi, JH Ryu, HW Lee, MJ Lee, JH Seo… - … of Chromatography B, 2009 - Elsevier
A rapid and simple procedure was developed for the determination of cephradine in human
plasma using liquid chromatography coupled with electrospray ionization-tandem mass …

[HTML][HTML] Pharmacological activity of cepharanthine

K Liu, B Hong, S Wang, F Lou, Y You, R Hu, A Shafqat… - Molecules, 2023 - mdpi.com
Cepharanthine, a natural bisbenzylisoquinoline (BBIQ) alkaloid isolated from the plant
Stephania Cephalantha Hayata, is the only bisbenzylisoquinoline alkaloid approved for …

Quantitative analysis of cepharanthine in plasma based on semiautomatic microextraction by packed sorbent combined with liquid chromatography

C Desgrouas, M Desbordes, J Dormoi… - Journal of Analytical …, 2014 - Wiley Online Library
The spread of Plasmodium falciparum resistance toward most of the used drugs requires
new antimalarial compounds. Taking advantage of the biodiversity, the …

Pharmacokinetic disposition of cepharanthin following single and multiple intravenous doses in healthy subjects

K YASUDA, M MORO, M AKASU… - Rinsho yakuri/Japanese …, 1989 - jstage.jst.go.jp
The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was investigated
in healthy subjects following single intravenous doses of 25, 50, and 100mg and during and …

Cepharanthine: An update of its mode of action, pharmacological properties and medical applications

C Bailly - Phytomedicine, 2019 - Elsevier
Background Cepharanthine (CEP) is a drug used in Japan since the 1950s to treat a
number of acute and chronic diseases, including treatment of leukopenia, snake bites …

[PDF][PDF] Pharmacokinetic study of cephradine in Pakistani healthy male volunteers

MH Shoaib, D Shaikh, RI Yousuf, BS Naqvi… - Pak J Pharm …, 2008 - academia.edu
To observe and discuss the difference in the pharmacokinetics of Cephradine in Pakistani
population with the reported data of other ethnic origins. A Single group pharmacokinetic …

Pharmacokinetic study of cepharanthin following single oral doses in healthy subjects

K YASUDA, M MORO, A OHNISHI… - … /Japanese Journal of …, 1989 - jstage.jst.go.jp
抄録 The pharmacokinetic disposition of Cepharanthin, a biscoclaurine alkaloid, was
investigatedin healthy subjects following single oral doses of 10, 30, 60, and 120mg. For 30 …