Normal cells do not divide indefinitely. This trait, termed the finite replicative life span of cells,
limits the capacity for cell division by a process termed cellular or replicative senescence …

Most cells cannot divide indefinitely due to a process termed cellular or replicative
senescence. Replicative senescence appears to be a fundamental feature of somatic cells …

Since the first cell culture was set at the beginning of the twentieth century it was believed
that all cultured cells, if provided with the proper conditions, would replicate indefinitely. Sixty …

Nearly 50 years have elapsed since Hayflick challenged the dogma that individual human
cells were immortal by demonstrating that after a predictable number of cellular divisions …

Normal cells do not divide indefinitely due to a process termed cellular or replicative
senescence. Several lines of evidence suggest that replicative senescence evolved to …

Normal human diploid fibroblasts (HDFs) undergo replicative senescence inevitably in
tissue culture after a certain number of cell divisions. A number of molecular changes …

The finite replicative life span of cells was formally described about 30 years ago (Hayflick
1965). Since then, the phenomenon has been studied by a number of investigators …

Differentiated eukaryotic cells have only a finite capacity for cell division. This limitation is
thought to be a cellular manifestation of organismal aging, and a restraint to tumor …

Normal cells, with few exceptions, cannot proliferate indefinitely. Cell populations—in vivo
and in culture—generally undergo only a limited number of doublings before proliferation …

Can studying cultured cells inform us about the biology of aging? The idea that this may be
was stimulated by the first formal description of replicative senescence. Replicative …