During normal spermatogenesis, more than half of the germ cells undergo apoptosis, but the
physiological significance and molecular mechanisms of this programmed cell death are …

Bcl6 protein has been detected in testicular germ cells, mainly spermatocytes, of normal
mice, but its physiological role is largely unknown. The number of spermatozoa in the cauda …

Bclw is a death-protecting member of the Bcl2 family of apoptosis-regulating proteins. Mice
that are mutant for Bclw display progressive and nearly complete testicular degeneration …

We investigated the frequency of spontaneous apoptosis and expression of the Bcl-2 family
of proteins during normal spermatogenesis in man. Testicular tissue with both normal …

A large part of germ cells die apoptotically during testicular development in rodents. In the
present study, a wave of germ cell apoptosis was observed between days 10 and 30 of …

Transgenic mice expressing high levels of the BclxL or Bcl2 proteins in the male germinal
cells show a highly abnormal adult spermatogenesis accompanied by sterility. This appears …

Using immunohistochemical techniques and Western blot analysis, the possible role of Bcl‐
2 family members Bax, Bcl‐2, Bcl‐xs, and Bcl‐xl in male germ cell density‐related apoptosis …

Proteins of the Bcl-2 family are important regulators of apoptosis in many tissues of the
embryo and adult. The recently isolated bcl-w gene encodes a pro-survival member of the …

Mature sperm are the product of a precisely regulated developmental sequence in which
germ cell proliferation, differentiation, self‐renewal and apoptosis are carefully controlled …

Bax is a multidomain, proapoptotic member of the Bcl-2 family that is required for normal
spermatogenesis in mice. Despite its proapoptotic function, previous results found that Bax …