Suppression of apoptosis by Bcl-2, an oncogene product, has been previously reported.
Although the down regulation of Bcl-2 has been encountered in various types of apoptosis …

Members of the Bcl-2 family serve as central checkpoints for cell death regulation, and
overexpression of Bcl-2 is known to inhibit apoptosis in many cell types. To determine …

The loss of ovarian follicles through atresia, which accounts for greater than 99% of
postnatal female germ cell depletion, is mediated through apoptotic cell death. Although …

Programmed cell death is an important regulatory event in spermatogenesis. However, the
molecular events governing apoptosis have not been characterized. Using the Leydig cell …

From the viewpoint of improving germ cell production and treatment of testicular cancers,
understanding the control of testicular cell death is of great relevance. One of the prominent …

The prostate gland in adult male rats is highly dependent on androgenic steroids. Castration
initiates the regression of this tissue through a process involving the loss of the vast majority …

Recent data support a role for apoptosis, under tight regulatory control by bcl-2, oxidative
stress response, tumor suppressor, and CASP gene family members, in mediating …

Germ cell apoptosis is very common during various stages of mammalian testicular
development. However, our understanding of the mechanisms underlying male germ cell …

Normal (nonneoplastic) human prostatic secretory epithelial cells do not express the bcl-2
protein. However, a recent immunohistochemical survey of neoplastic human prostate …

The present study investigates the molecular apoptotic pathway in germ cells following
acute ischemia of the rat testis. Rats were subjected to ischemia-inducing torsion and testes …