Epidemiological surveys and animal experimental studies suggest that exposure to 2-
bromopropme (2-BP) could result in reproductive and hematopoietic disorders. The …

BACKGROUND Several recent studies have suggested an important role of the apoptosis
suppressing Bcl‐2 gene product in prostate cancer progression to an androgen‐insensitive …

Apoptosis during preimplantation development has received much interest because of its
potential role in eliminating defective cells. Although development in humans is …

Spontaneous germ cell death is a common cellular process in the mammalian testis,
although the function of this process during spermatogenesis is unclear. An investigation …

Apoptosis is a process of cell suicide, the mechanisms of which are encoded in the
chromosomes of all nucleated cells. Apoptosis occurs spontaneously throughout …

Abstract In women, up to 99.9% of the oocyte stockpile formed during fetal life is decimated
by apoptosis. Apoptotic features are also detected in human preimplantation embryos both …

To clarify whether germ cell apoptosis is related to a decrease of germ cells in the aged
testis with impaired spermatogenesis, we investigated the apoptotic rate of each germ cell …

The significance of apoptosis in relation to the development and progression of prostate
cancer remains largely undefined, bcl-2 is an oncogene that functions by overriding …

Male germ cell apoptosis has been extensively explored in rodents. In contrast, very little is
known about the susceptibility of developing germ cells to apoptosis in response to busulfan …

The BH3‐only proteins of the Bcl‐2 family initiate apoptosis through the activation of Bax‐
like relatives. Loss of individual BH3‐only proteins can lead either to no phenotype, as in …