[HTML][HTML] Hydrogen sulfide acts as a double-edged sword in human hepatocellular carcinoma cells through EGFR/ERK/MMP-2 and PTEN/AKT signaling pathways

D Wu, M Li, W Tian, S Wang, L Cui, H Li, H Wang… - Scientific Reports, 2017 - nature.com
Hydrogen sulfide (H2S) is involved in cancer biological processes. However, there are
several controversies concerning the role of H2S in cancer development and progression. In …

Hydrogen sulfide is a signaling molecule and a cytoprotectant

H Kimura, N Shibuya, Y Kimura - Antioxidants & redox signaling, 2012 - liebertpub.com
Significance: Accumulating evidence shows that hydrogen sulfide may function as a
signaling molecule in processes such as neuromodulation in the brain and smooth muscle …

[HTML][HTML] Hydrogen sulfide: biogenesis, physiology, and pathology

JS Bian, KR Olson, YC Zhu - Oxidative Medicine and Cellular …, 2016 - ncbi.nlm.nih.gov
The seminal studies by Kimura's group in the late 1990s [1, 2] ushered in a new era of
biological signaling mediated by hydrogen sulfide (H2S). H2S has been described as the …

[HTML][HTML] Recent development of hydrogen sulfide releasing/stimulating reagents and their potential applications in cancer and glycometabolic disorders

C Yang, L Chen, S Xu, JJ Day, X Li… - Frontiers in …, 2017 - frontiersin.org
As an important endogenous gaseous signaling molecule, hydrogen sulfide (H2S) exerts
various effects in the body. A variety of pathological changes, such as cancer …

Exogenous hydrogen sulfide inhibits human melanoma cell development via suppression of the PI3K/AKT/mTOR pathway

Q Xiao, J Ying, Z Qiao, Y Yang, X Dai, Z Xu… - Journal of …, 2020 - Elsevier
Background: Melanoma is one of the most aggressive, therapy-resistant skin cancers in the
world. Hydrogen sulfide (H 2 S), a newly discovered gasotransmitter, plays a crucial role in …

[HTML][HTML] Targeting homocysteine and hydrogen sulfide balance as future therapeutics in cancer treatment

A Majumder - Antioxidants, 2023 - mdpi.com
A high level of homocysteine (Hcy) is associated with oxidative/ER stress, apoptosis, and
impairment of angiogenesis, whereas hydrogen sulfide (H2S) has been found to reverse this …

Hydrogen sulfide (H2S) metabolism: Unraveling cellular regulation, disease implications, and therapeutic prospects for precision medicine

T Pandey, V Pandey - Nitric Oxide, 2024 - Elsevier
Abstract Hydrogen sulfide (H 2 S), traditionally recognized as a noxious gas with a pungent
odor, has emerged as a fascinating metabolite originating from proteinaceous foods. This …

Hydrogen sulfide: a novel mediator of leukocyte activation

H Zhang, M Bhatia - Immunopharmacology and immunotoxicology, 2008 - Taylor & Francis
Accumulating evidence has suggested that hydrogen sulfide (H2S) is endogenously
generated in many types of mammalian cells. Since H2S plays an important role in …

[HTML][HTML] The double-edged role of hydrogen sulfide in the pathomechanism of multiple liver diseases

B Liu, S Wang, M Xu, Y Ma, R Sun, H Ding… - Frontiers in …, 2022 - frontiersin.org
In mammalian systems, hydrogen sulfide (H2S)—one of the three known gaseous signaling
molecules in mammals—has been found to have a variety of physiological functions …

Fluorescent probes for hydrogen sulfide detection

B Peng, M Xian - Asian Journal of Organic Chemistry, 2014 - Wiley Online Library
Hydrogen sulfide (H2S) is an important signaling molecule with potent cytoprotective
actions. Current results strongly suggest that modulation of H2S levels could have potential …