Interleukin 15 is essential for the development and differentiation of NK and memory
CD8+(mCD8+) T cells. Our laboratory previously showed that NK and CD8+ T lymphocytes …

IL-15 is a pluripotent antiapoptotic cytokine that signals to cells of both the innate and
adaptive immune system and is regarded as a highly promising immunomodulatory agent in …

The objective of the study was to investigate the mechanisms of insufficient interferon-γ (IFN-
γ) response to interleukin 18 (IL-18) and the treatment for the insufficient response in septic …

The sepsis syndrome represents an improper immune response to infection and is
associated with unacceptably high rates of mortality and morbidity. The interactions between …

Background Severely burned patients are highly susceptible to opportunistic infections and
sepsis, owing to the loss of the protective skin barrier and immunological dysfunction …

Sepsis, a disease of divergent pro-and anti-inflammatory–mediated pathways, has a high
prevalence of morbidity and mortality, yet an understanding of potential unifying mediators …

The dysregulated sepsis-induced cytokine storm evoked during systemic infection consists
of biphasic and interconnected pro-and anti-inflammatory responses. The contrasting …

Identification of new therapeutic targets for the treatment of sepsis is imperative. We report
here that cytokine IL-28 (IFN-λ) levels were elevated in clinical and experimental sepsis …

Interleukin (IL)-10 is an anti-inflammatory cytokine known to modulate the outcome of sepsis
by decreasing pro-inflammatory cytokine production, including IL-12, a main activator of …

Sepsis is a systemic inflammatory response resulting from the inability of the host to contain
the infection locally. Previously, we demonstrated that during severe sepsis there is a …