Genome editing technologies have advanced significantly over the past few years, providing
a fast and effective tool to precisely manipulate the genome at specific locations. The three …

The use of precise, rationally designed gene-editing nucleases allows for targeted genome
and transcriptome modification, and at present, four major classes of nucleases are being …

Gene therapy has historically been defined as the addition of new genes to human cells.
However, the recent advent of genome-editing technologies has enabled a new paradigm in …

The possibility of editing complex genomes in a targeted fashion has revolutionized basic
research as well as biomedical and biotechnological applications in the last 5 years. The …

The rapid advancement of genome-editing techniques holds much promise for the field of
human gene therapy. From bacteria to model organisms and human cells, genome editing …

The last two decades have marked significant advancement in the genome editing field.
Three generations of programmable nucleases (ZFNs, TALENs, and CRISPR-Cas system) …

Based on engineered or bacterial nucleases, the development of genome editing
technologies has opened up the possibility of directly targeting and modifying genomic …

The development of custom-designed nucleases (CDNs), including zinc finger nucleases
(ZFNs) and transcription activator-like effector nucleases (TALENs), has made it possible to …

Targeted genome editing is an advanced technique that enables precise modification of the
nucleic acid sequences in a genome. Genome editing is typically performed using tools …

Gene therapy refers to the addition of new genes to human cells, while genome editing
involves the precise manipulation of the sequence of the human genome for disease …