An N-terminally truncated third progesterone receptor protein, PRC, forms heterodimers with PRB but interferes in PRB-DNA binding

LL Wei, BM Norris, CJ Baker - The Journal of steroid biochemistry and …, 1997 - Elsevier
Multiple progesterone receptor (PR) isoforms may explain in part the complex and diverse
biological actions of progestins. Recent studies demonstrate that the human 116 kDa B …

An amino-terminal truncated progesterone receptor isoform, PRc, enhances progestin-induced transcriptional activity.

LL Wei, P Hawkins, C Baker, B Norris… - Molecular …, 1996 - academic.oup.com
Previously we reported the identification of two unique progesterone receptor (PR)
messenger RNA transcripts that encode a smaller PR isoform, termed the C-receptor (PRc) …

[HTML][HTML] Mapping and characterization of the functional domains responsible for the differential activity of the A and B isoforms of the human progesterone receptor

PH Giangrande, G Pollio, DP McDonnell - Journal of Biological Chemistry, 1997 - ASBMB
In humans, the biological response to progesterone is mediated by two distinct forms of the
progesterone receptor (human (h) PR-A, 94 kDa and hPR-B, 114 kDa). These two isoforms …

Antagonist-occupied human progesterone B-receptors activate transcription without binding to progesterone response elements and are dominantly inhibited by A …

L Tung, MK Mohamed, JP Hoeffler… - Molecular …, 1993 - academic.oup.com
When antagonist-occupied steroid receptors have agonist-like effects, the clinical
consequences are grave. We present evidence that human progesterone B-receptors …

[PDF][PDF] Reproductive functions of progesterone receptors

OM Conneely, B Mulac-Jericevic, F DeMayo… - Recent progress in …, 2002 - endocrine.org
The steroid hormone progesterone plays a central role in the reproductive events associated
with pregnancy establishment and maintenance. Physiological effects of progesterone are …

The A and B isoforms of the human progesterone receptor operate through distinct signaling pathways within target cells

DX Wen, YF Xu, DE Mais, ME Goldman… - … and cellular biology, 1994 - Taylor & Francis
The biological response to progesterone is mediated by two distinct forms of the human
progesterone receptor (hPR-A and hPR-B). In most cell contexts, hPR-B functions as a …

Progesterone-dependent regulation of female reproductive activity by two distinct progesterone receptor isoforms

OM Conneely, B Mulac-Jericevic, JP Lydon - Steroids, 2003 - Elsevier
The steroid hormone, progesterone, is a central coordinator of all aspects of female
reproductive activity. The physiological effects of progesterone are mediated by interaction …

The A and B isoforms of the human progesterone receptor: two functionally different transcription factors encoded by a single gene.

PH Giangrande, DP McDonnell - Recent progress in hormone …, 1999 - europepmc.org
In humans, the biological response to progesterone is mediated by two forms of the
progesterone receptor (hPR-A; 94kDa and hPR-B; 114kDa). These two isoforms are …

Definition of a negative modulation domain in the human progesterone receptor

B Huse, SB Verca, P Matthey… - Molecular …, 1998 - academic.oup.com
The progesterone receptor (PR) occurs in two major forms, the full-length PRB and the
amino-truncated PRA, which lacks 164 amino-terminal residues. PRB functions as a strong …

Hormone-Dependent Interaction between the Amino- and Carboxyl-Terminal Domains of Progesterone Receptor in Vitro and in Vivo

MJ Tetel, PH Giangrande, SA Leonhardt… - Molecular …, 1999 - academic.oup.com
Full transcriptional activation by steroid hormone receptors requires functional synergy
between two transcriptional activation domains (AF) located in the amino (AF-1) and …