Background Drug combination therapy, which is considered as an alternative to single drug
therapy, can potentially reduce resistance and toxicity, and have synergistic efficacy. As drug …

Objective Synergistic drug combinations are promising therapies for cancer treatment.
However, effective prediction of synergistic drug combinations is quite challenging as …

Chemotherapy is a routine treatment approach for early-stage cancers, but the effectiveness
of such treatments is often limited by drug resistance, toxicity, and tumor heterogeneity …

Drug combinations have been proposed as a promising therapeutic strategy to overcome
drug resistance and improve efficacy of monotherapy regimens in cancer. This strategy aims …

High-throughput drug screening has facilitated the discovery of drug combinations in cancer.
Many existing studies adopted a full matrix design, aiming for the characterization of drug …

Drug combination therapies can improve drug efficacy, reduce drug dosage, and overcome
drug resistance in cancer treatments. Current research strategies to determine which drug …

Drug combinations are of great interest for cancer treatment. Unfortunately, the discovery of
synergistic combinations by purely experimental means is only feasible on small sets of …

Combination therapies are commonly used to treat patients with complex diseases that
respond poorly to single-agent therapies. In vitro high-throughput drug screening is a …

Combinational pharmacotherapy with the synergistic/additive effect is a powerful treatment
strategy for complex diseases such as malignancies. Identifying synergistic combinations …

Drug combination therapy has become a promising therapeutic strategy for cancer
treatment. While high-throughput drug combination screening is effective for identifying …