Signaling pathways in the regulation of cancer stem cells and associated targeted therapy

W Manni, W Min - MedComm, 2022 - Wiley Online Library
Cancer stem cells (CSCs) are defined as a subpopulation of malignant tumor cells with
selective capacities for tumor initiation, self‐renewal, metastasis, and unlimited growth into …

Targeting cancer stem cell pathways for cancer therapy

L Yang, P Shi, G Zhao, J Xu, W Peng, J Zhang… - Signal transduction and …, 2020 - nature.com
Since cancer stem cells (CSCs) were first identified in leukemia in 1994, they have been
considered promising therapeutic targets for cancer therapy. These cells have self-renewal …

Cancer stem cells: perspectives for therapeutic targeting

C Maccalli, R De Maria - Cancer immunology, immunotherapy, 2015 - Springer
Cells with “stemness” and tumor-initiating properties have been isolated from both
hematological and solid tumors. These cells denominated as cancer stem cells (CSCs) …

Profiling and targeting cancer stem cell signaling pathways for cancer therapeutics

MC Borlongan, H Wang - Frontiers in Cell and Developmental Biology, 2023 - frontiersin.org
Tumorigenic cancer stem cells (CSCs) represent a subpopulation of cells within the tumor
that express genetic and phenotypic profiles and signaling pathways distinct from the other …

Evolving strategies for therapeutically targeting cancer stem cells

S Talukdar, L Emdad, SK Das, D Sarkar… - Advances in Cancer …, 2016 - Elsevier
Cancer is a multifactor and multistep process that is affected intrinsically by the genetic and
epigenetic makeup of tumor cells and extrinsically by the host microenvironment and …

New opportunities and challenges to defeat cancer stem cells

EK Ramos, AD Hoffmann, SL Gerson, H Liu - Trends in cancer, 2017 - cell.com
Cancer stem cells (CSCs) are a subpopulation of cancer cells that are capable of self-
renewal, proliferation, differentiation, plastic adaptation, and immune regulation, thereby …

Bidirectional crosstalk between cancer stem cells and immune cell subsets

L Müller, A Tunger, I Plesca, R Wehner… - Frontiers in …, 2020 - frontiersin.org
Cancer stem cells (CSCs), also known as tumor-initiating cells, are characterized by an
increased capacity for self-renewal, multipotency, and tumor initiation. While CSCs …

Regulation and signaling pathways in cancer stem cells: implications for targeted therapy for cancer

Z Zeng, M Fu, Y Hu, Y Wei, X Wei, M Luo - Molecular Cancer, 2023 - Springer
Cancer stem cells (CSCs), initially identified in leukemia in 1994, constitute a distinct subset
of tumor cells characterized by surface markers such as CD133, CD44, and ALDH. Their …

Targeting signalling pathways and the immune microenvironment of cancer stem cells—a clinical update

JA Clara, C Monge, Y Yang, N Takebe - Nature reviews clinical …, 2020 - nature.com
Cancer stem cells (CSCs) have important roles in tumour development, relapse and
metastasis; the intrinsic self-renewal characteristics and tumorigenic properties of these cells …

Targeting cancer stem cells by inhibiting Wnt, Notch, and Hedgehog pathways

N Takebe, PJ Harris, RQ Warren, SP Ivy - Nature reviews Clinical …, 2011 - nature.com
Tumor relapse and metastasis remain major obstacles for improving overall cancer survival,
which may be due at least in part to the existence of cancer stem cells (CSCs). CSCs are …