Background: Acute administration of mitochondrial adenosine triphosphate–dependent
potassium channel openers preconditions the heart, but whether their long-term …

In cells, hyperthermia induces synthesis of heat-shock proteins and the acquisition of
thermotolerance. Thermotolerant cells are resistant to subsequent oxidative stress. In this …

• Intraoperative myocardial protection was evaluated in two groups of patients undergoing
coronary surgery in whom different techniques for cardiac arrest were utilized. In group A …

We tested the ability of various cardiac preservation techniques to preserve left ventricular
function of isolated canine hearts using preservation temperatures of 4° or 15° C. The four …

We have previously shown that an intracellular-like crystalloid cardioplegic solution (ICS)
provides superior protection to normothermic canine hearts subjected to 1 hour of global …

The purpose of this study was to assess the ability of hypoxic preconditioning to improve
myocardial salvage after prolonged hypothermic cardioplegic arrest. Isolated working rat …

The extent of myocardial protection afforded by a procaine cardioplegic solution during
cardiac ischemia has been evaluated and compared with the protection seen using a …

Recent evidence suggests that postischemic contractile dysfunction of viable myocardium
salvaged by reperfusion (“stunned myocardium”) may be a consequence of abnormal …

Hypothermia is known to protect myocardium during ischemia, but its role in induction of a
protective stress response before ischemia has not been evaluated. As cold incites stress …

During cardiac surgery or cardiac transplantation, the heart is subjected to varying periods of
global ischemia. The heart must be protected during this ischemic period to avoid additional …