CC and CXC chemokines are pivotal mediators of cerebral injury in ischaemic stroke

M Mirabelli-Badenier, V Braunersreuther… - Thrombosis and …, 2011 - thieme-connect.com
The definition of ischaemic stroke has been recently updated as an acute episode of
neurological dysfunction caused by focal brain, spinal cord, or retinal ischaemia in the …

[HTML][HTML] Inflammation after ischemic stroke: the role of leukocytes and glial cells

JY Kim, J Park, JY Chang, SH Kim… - Experimental …, 2016 - ncbi.nlm.nih.gov
The immune response after stroke is known to play a major role in ischemic brain
pathobiology. The inflammatory signals released by immune mediators activated by brain …

[HTML][HTML] Brain immune interactions—novel emerging options to treat acute ischemic brain injury

S Muhammad, SR Chaudhry, UD Kahlert, M Niemelä… - Cells, 2021 - mdpi.com
Ischemic stroke is still among the leading causes of mortality and morbidity worldwide.
Despite intensive advancements in medical sciences, the clinical options to treat ischemic …

The evolving role of neuro‐immune interaction in brain repair after cerebral ischemic stroke

X Wang, W Xuan, ZY Zhu, Y Li, H Zhu… - CNS neuroscience & …, 2018 - Wiley Online Library
Stroke is the world's leading cause of disability with limited brain repair treatments which
effectively improve long‐term neurological deficits. The neuroinflammatory responses …

[HTML][HTML] Post-ischemic inflammatory response in the brain: Targeting immune cell in ischemic stroke therapy

X Shen, M Li, K Shao, Y Li, Z Ge - Frontiers in Molecular …, 2023 - frontiersin.org
An ischemic stroke occurs when the blood supply is obstructed to the vascular basin,
causing the death of nerve cells and forming the ischemic core. Subsequently, the brain …

The role of neutrophils and interleukin-8 in acute ischemic stroke

FM Domac, H Misirli - Neurosciences Journal, 2008 - nsj.org.sa
OBJECTIVE: To investigate the crucial role of interleukin 8 (IL-8) as an inflammatory marker
in infarct evolution, and course of the disease. METHODS: The study included 76 patients …

[HTML][HTML] Monocyte transmodulation: the next novel therapeutic approach in overcoming ischemic stroke?

J Park, JY Chang, JY Kim, JE Lee - Frontiers in neurology, 2020 - frontiersin.org
The immune response following neuroinflammation is a vital element of ischemic stroke
pathophysiology. After the onset of ischemic stroke, a specialized vasculature system that …

Alterations of inflammatory cytokines in super-acute stroke patients and the potential pathogenesis

F Li, Q Ma, L Li, L Zhang, Z Yang, Y Huang… - Journal of Clinical …, 2022 - Elsevier
Background Sufficient understanding of the systemic inflammatory response after stroke will
make the therapeutic strategy targeting inflammation more feasible. Here, we aimed to …

Interleukin 8 (CXCL8)-CXC chemokine receptor 2 (CXCR2) axis contributes to MiR-4437-associated recruitment of granulocytes and natural killer cells in ischemic …

Q He, X Shi, B Zhou, J Teng, C Zhang, S Liu, J Lian… - Molecular …, 2018 - Elsevier
Granulocytes and natural killer (NK) cells have been linked to brain injury in ischemic stroke.
However, their recruitment from peripheral leucocytes in stroke patients is not well …

[HTML][HTML] The hallmark and crosstalk of immune cells after intracerebral hemorrhage: Immunotherapy perspectives

W Zhang, Q Wu, S Hao, S Chen - Frontiers in Neuroscience, 2023 - frontiersin.org
Intracerebral hemorrhage (ICH) is one of the most dangerous types of strokes with a high
morbidity and mortality rate. Currently, the treatment of ICH is not well developed, mainly …