Genome-wide analysis of HPV integration in human cancers reveals recurrent, focal genomic instability

K Akagi, J Li, TR Broutian, H Padilla-Nash… - Genome …, 2014 - genome.cshlp.org
Genomic instability is a hallmark of human cancers, including the 5% caused by human
papillomavirus (HPV). Here we report a striking association between HPV integration and …

Genome-wide profiling of HPV integration in cervical cancer identifies clustered genomic hot spots and a potential microhomology-mediated integration mechanism

Z Hu, D Zhu, W Wang, W Li, W Jia, X Zeng, W Ding… - Nature …, 2015 - nature.com
Human papillomavirus (HPV) integration is a key genetic event in cervical carcinogenesis.
By conducting whole-genome sequencing and high-throughput viral integration detection …

Intratumoral heterogeneity and clonal evolution induced by HPV integration

K Akagi, DE Symer, M Mahmoud, B Jiang, S Goodwin… - Cancer discovery, 2023 - AACR
The human papillomavirus (HPV) genome is integrated into host DNA in most HPV-positive
cancers, but the consequences for chromosomal integrity are unknown. Continuous long …

[HTML][HTML] Recurrent integration of human papillomavirus genomes at transcriptional regulatory hubs

A Warburton, TE Markowitz, JP Katz, JM Pipas… - NPJ Genomic …, 2021 - nature.com
Oncogenic human papillomavirus (HPV) genomes are often integrated into host
chromosomes in HPV-associated cancers. HPV genomes are integrated either as a single …

[HTML][HTML] Mechanism of genomic instability in cells infected with the high-risk human papillomaviruses

M Kadaja, H Isok-Paas, T Laos, E Ustav… - PLoS …, 2009 - journals.plos.org
In HPV–related cancers, the “high-risk” human papillomaviruses (HPVs) are frequently
found integrated into the cellular genome. The integrated subgenomic HPV fragments …

[HTML][HTML] Mechanistic signatures of HPV insertions in cervical carcinomas

A Holmes, S Lameiras, E Jeannot, Y Marie… - NPJ genomic …, 2016 - nature.com
To identify new personal biomarkers for the improved diagnosis, prognosis and biological
follow-up of human papillomavirus (HPV)-associated carcinomas, we developed a generic …

[HTML][HTML] Long-read sequencing unveils high-resolution HPV integration and its oncogenic progression in cervical cancer

L Zhou, Q Qiu, Q Zhou, J Li, M Yu, K Li, L Xu… - Nature …, 2022 - nature.com
Integration of human papillomavirus (HPV) DNA into the human genome is considered as a
key event in cervical carcinogenesis. Here, we perform comprehensive characterization of …

Genomic characterization of viral integration sites in HPV‐related cancers

C Bodelon, ME Untereiner, MJ Machiela… - … journal of cancer, 2016 - Wiley Online Library
Persistent infection with carcinogenic human papillomaviruses (HPV) causes the majority of
anogenital cancers and a subset of head and neck cancers. The HPV genome is frequently …

Long-read sequencing reveals oncogenic mechanism of HPV-human fusion transcripts in cervical cancer

M Liu, Z Han, Y Zhi, Y Ruan, G Cao, G Wang, X Xu… - Translational …, 2023 - Elsevier
Integration of high-risk human papillomavirus (HPV) into the host genome is a crucial event
for the development of cervical cancer, however, the underlying mechanism of HPV …

[HTML][HTML] HPV integration hijacks and multimerizes a cellular enhancer to generate a viral-cellular super-enhancer that drives high viral oncogene expression

A Warburton, CJ Redmond, KE Dooley, H Fu… - PLoS …, 2018 - journals.plos.org
Integration of human papillomavirus (HPV) genomes into cellular chromatin is common in
HPV-associated cancers. Integration is random, and each site is unique depending on how …