There is a growing concern related to the use of opioid maintenance treatment during
pregnancy. Studies in both humans and animals have reported reduced cognitive …

Background Concerns have been raised about the use of opioid maintenance treatment
(OMT) during pregnancy and negative effects for the offspring. While neonatal outcomes and …

Prenatal opioid exposures lead to extensive cognitive and emotion‐regulation problems in
children, persisting at least through school‐age. Methadone, an opioid typically used for the …

Previous in vivo studies revealed that buprenorphine can down-regulate μ and up-regulate
δ2 and κ1 opioid receptors in adult and neonatal rat brain. To assess gestational effects of …

Gestational actions of the mixed agonist-antagonist buprenorphine on μ-and κ 1-opioid
binding in neonatal and maternal rat brain were investigated. Upon exposure of pregnant …

In addition to its use for heroin addiction pharmacotherapy in general, buprenorphine has
advantages in treating maternal heroin abuse. To examine the gestational effects of …

Buprenorphine is a μ‐opioid receptor partial agonist and κ‐opioid receptor antagonist
currently on trials for the management of pregnant opioid‐dependent addicts. However, little …

The biochemical and cellular mechanisms involved in the development and/or maintenance
of morphine tolerance remain unclear. In the adult central nervous system (CNS) results are …

The effects of chronic prenatal methadone exposure (6.3–9.0 mg/kg/day) via osmotic
minipumps to pregnant dams on fetal and maternal brain opioid μ-receptors were assessed …

Experimental animal studies are valuable in revealing a causal relationship between
prenatal exposure to opioid maintenance treatment (OMT) and subsequent effects; however …