P4HA3 is Epigenetically Activated by Slug in Gastric Cancer and its Deregulation is Associated With Enhanced Metastasis and Poor Survival
H Song, L Liu, Z Song, Y Ren, C Li… - Technology in cancer …, 2018 - journals.sagepub.com
Prolyl 4-hydroxylase alpha subunit is the enzymic active site of prolyl 4-hydroxylase, which
is a critical enzyme to maintain the stability of newly synthesized collagens. The expression …
is a critical enzyme to maintain the stability of newly synthesized collagens. The expression …
Prolyl 4-hydroxylase subunit alpha 3 facilitates human colon cancer growth and metastasis through the TGF-β/Smad signaling pathway
H Zhou, J Zou, C Shao, A Zhou, J Yu, S Chen… - Pathology-Research and …, 2022 - Elsevier
Abstract Prolyl 4-hydroxylase subunit alpha 3 (P4HA3) has been known to be associated
with a variety of human cancers. However, the role of P4HA3 on colon cancer growth and …
with a variety of human cancers. However, the role of P4HA3 on colon cancer growth and …
The prognostic significance and potential mechanism of prolyl 3‐hydroxylase 1 in hepatocellular carcinoma
C Li, L Zhang, Y Xu, D Chai, S Nan, Z Qiu… - Journal of …, 2022 - Wiley Online Library
Background. Prolyl 3‐hydroxylase 1 (P3H1) is essential for human collagen synthesis. Here,
we investigated its relevance to multiple cancers, especially hepatocellular carcinoma …
we investigated its relevance to multiple cancers, especially hepatocellular carcinoma …
Prolyl-4-hydroxylase α subunit 2 promotes breast cancer progression and metastasis by regulating collagen deposition
G Xiong, L Deng, J Zhu, PG Rychahou, R Xu - BMC cancer, 2014 - Springer
Background Increased collagen deposition provides physical and biochemical signals to
support tumor growth and invasion during breast cancer development. Therefore, inhibition …
support tumor growth and invasion during breast cancer development. Therefore, inhibition …
Systematic Analysis of the Expression and Prognostic Significance of P4HA1 in Pancreatic Cancer and Construction of a lncRNA‐miRNA‐P4HA1 Regulatory Axis
Z Hu, F Song, Y Hu, T Liao - BioMed Research International, 2020 - Wiley Online Library
Objectives. Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) plays a crucial role in modulating
extracellular matrix component and promoting tumor progression by changing tumor …
extracellular matrix component and promoting tumor progression by changing tumor …
Identification of Potential Diagnostic and Prognostic Values of P4HA1 Expression in Lung Cancer, Breast Cancer, and Head and Neck Cancer
M Li, F Wu, Q Zheng, Y Wu, Y Wu - DNA and Cell Biology, 2020 - liebertpub.com
The aims of this study were to investigate the expression of prolyl 4-hydroxylase subunit
alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC) …
alpha-1 (P4HA1) and its relationship with clinicopathological features in lung cancer (LC) …
High P4HA1 expression is an independent prognostic factor for poor overall survival and recurrent‐free survival in head and neck squamous cell carcinoma
Q Li, Z Shen, Z Wu, Y Shen, H Deng… - Journal of clinical …, 2020 - Wiley Online Library
Background Prolyl 4‐hydroxylase subunit alpha 1 (P4HA1) plays a critical role in modulating
the extracellular matrix and promoting tumor progression in various cancers. However, the …
the extracellular matrix and promoting tumor progression in various cancers. However, the …
P4HA2 Promotes Epithelial‐to‐Mesenchymal Transition and Glioma Malignancy through the Collagen‐Dependent PI3K/AKT Pathway
J Lin, L Jiang, X Wang, W Wei, C Song… - Journal of …, 2021 - Wiley Online Library
Prolyl‐4‐hydroxylase subunit 2 (P4HA2) is a member of collagen modification enzymes
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
involved in the remodeling of the extracellular matrix (ECM). Mounting evidence has …
[HTML][HTML] Collagen prolyl 4-hydroxylase 2 predicts worse prognosis and promotes glycolysis in cervical cancer
Q Li, Q Wang, Q Zhang, J Zhang… - American Journal of …, 2019 - ncbi.nlm.nih.gov
P4HA2 is one of collagen prolyl 4-hydroxylase (P4H) isoform and increased in several types
of human cancer. However, the role of P4HA2 during cervical tumorigenesis remains largely …
of human cancer. However, the role of P4HA2 during cervical tumorigenesis remains largely …
Prolyl 4-hydroxylase subunit alpha 3 presents a cancer promotive function in head and neck squamous cell carcinoma via regulating epithelial-mesenchymal …
T Wang, YX Wang, YQ Dong, YL Yu, K Ma - Archives of Oral Biology, 2020 - Elsevier
Objective This study aimed to explore the prognostic value and functional role of Prolyl 4-
Hydroxylase Subunit Alpha 3 (P4HA3) in head and neck squamous cell carcinoma. Methods …
Hydroxylase Subunit Alpha 3 (P4HA3) in head and neck squamous cell carcinoma. Methods …