Y-box binding protein 1–a prognostic marker and target in tumour therapy

C Kosnopfel, T Sinnberg, B Schittek - European journal of cell biology, 2014 - Elsevier
Y-box binding protein 1 (YB-1) is a multifunctional protein involved in various cellular
processes including both transcriptional and translational regulation of target gene …

YB-1: oncoprotein, prognostic marker and therapeutic target?

A Lasham, CG Print, AG Woolley, SE Dunn… - Biochemical …, 2013 - portlandpress.com
Hanahan and Weinberg have proposed the 'hallmarks of cancer'to cover the biological
changes required for the development and persistence of tumours [Hanahan and Weinberg …

[HTML][HTML] Role of Y Box Protein-1 in cancer: As potential biomarker and novel therapeutic target

PK Maurya, A Mishra, BS Yadav, S Singh… - Journal of …, 2017 - ncbi.nlm.nih.gov
The Y-box binding protein (YB-1) is known to be a multifunctional transcription and
translation factor during expression of several proteins. It is a vital oncoprotein that regulates …

The increased expression of Y box‐binding protein 1 in melanoma stimulates proliferation and tumor invasion, antagonizes apoptosis and enhances chemoresistance

B Schittek, K Psenner, B Sauer, F Meier… - … journal of cancer, 2007 - Wiley Online Library
In previous studies we identified the transcription/translation factor Y‐box‐binding protein
(YB‐1) as a gene that is upregulated in primary melanoma and melanoma metastases when …

[HTML][HTML] YB-1 as an oncoprotein: functions, regulation, post-translational modifications, and targeted therapy

Q Yin, M Zheng, Q Luo, D Jiang, H Zhang, C Chen - Cells, 2022 - mdpi.com
Y box binding protein 1 (YB-1) is a protein with a highly conserved cold shock domain (CSD)
that also belongs to the family of DNA-and RNA-binding proteins. YB-1 is present in both the …

[HTML][HTML] Y-box binding protein-1 regulates cell proliferation and is associated with clinical outcomes of osteosarcoma

Y Fujiwara-Okada, Y Matsumoto, J Fukushi… - British journal of …, 2013 - nature.com
Background: Prognosis of osteosarcoma (OS) with distant metastasis and local recurrence is
still poor. Y-box binding protein-1 (YB-1) is a multifunctional protein that can act as a …

Elevated nuclear YB1 expression is associated with poor survival of patients with early breast cancer

A Maciejczyk, J Szelachowska, M Ekiert… - Anticancer …, 2012 - ar.iiarjournals.org
Background: Y-Box–Binding (YB1) protein represents a multifunctional protein, which plays
a significant role in processes of proliferation, apoptosis and control of tumour cell response …

[HTML][HTML] YB-1 is a transcription/translation factor that orchestrates the oncogenome by hardwiring signal transduction to gene expression

J Wu, AL Stratford, A Astanehe… - Translational …, 2007 - ncbi.nlm.nih.gov
Abstract The Y-box Binding Protein-1 (YB-1) is a highly conserved oncogenic transcription/
translation factor that is expressed in cancers affecting adults and children. It is now believed …

[HTML][HTML] Tumour progression stage-dependent secretion of YB-1 stimulates melanoma cell migration and invasion

C Kosnopfel, T Sinnberg, B Sauer, H Niessner… - Cancers, 2020 - mdpi.com
Secreted factors play an important role in intercellular communication. Therefore, they are
not only indispensable for the regulation of various physiological processes but can also …

[HTML][HTML] High expression of Y-box-binding protein 1 is associated with local recurrence and predicts poor outcome in patients with colorectal cancer

X Yan, L Yan, S Liu, Z Shan, C Jiang… - International Journal of …, 2014 - ncbi.nlm.nih.gov
Colorectal cancer (CRC) is one of the most common and fatal malignancies worldwide.
Novel prognostic biomarkers are urgently warranted to help improve the treatment of CRC. Y …