miR-340 inhibits tumor cell proliferation and induces apoptosis by targeting multiple negative regulators of p27 in non-small cell lung cancer
S Fernandez, M Risolino, N Mandia, F Talotta, Y Soini… - Oncogene, 2015 - nature.com
MicroRNAs (miRNAs) control cell cycle progression by targeting the transcripts encoding for
cyclins, CDKs and CDK inhibitors, such as p27 KIP1 (p27). p27 expression is controlled by …
cyclins, CDKs and CDK inhibitors, such as p27 KIP1 (p27). p27 expression is controlled by …
[HTML][HTML] miR‑221‑3p promotes the cell growth of non‑small cell lung cancer by targeting p27
G Yin, B Zhang, J Li - Molecular Medicine Reports, 2019 - spandidos-publications.com
Emerging evidence suggests the critical function of microRNAs in regulating the growth of
cancer cells. In the present study, it was demonstrated that miR‑221‑3p was overexpressed …
cancer cells. In the present study, it was demonstrated that miR‑221‑3p was overexpressed …
[HTML][HTML] miR-195 targets cyclin D3 and survivin to modulate the tumorigenesis of non-small cell lung cancer
Abstract miR-195 has recently been reported to function as a tumor suppressor in various
cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which …
cancers, including non-small cell lung cancer (NSCLC). However, the mechanisms by which …
miR-186 downregulation correlates with poor survival in lung adenocarcinoma, where it interferes with cell-cycle regulation
Deeper mechanistic understanding of lung adenocarcinoma (non–small cell lung
carcinoma, or NSCLC), a leading cause of cancer-related deaths overall, may lead to more …
carcinoma, or NSCLC), a leading cause of cancer-related deaths overall, may lead to more …
Regulation of the p27Kip1 tumor suppressor by miR‐221 and miR‐222 promotes cancer cell proliferation
C Le Sage, R Nagel, DA Egan, M Schrier… - The EMBO …, 2007 - embopress.org
MicroRNAs (miRNAs) are potent post‐transcriptional regulators of protein coding genes.
Patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in …
Patterns of misexpression of miRNAs in cancer suggest key functions of miRNAs in …
Co-suppression of miR-221/222 cluster suppresses human glioma cell growth by targeting p27kip1 in vitro and in vivo
C Zhang, C Kang, Y You, P Pu… - International …, 2009 - spandidos-publications.com
MicroRNAs are short regulatory RNAs that negatively modulate protein expression at a post-
transcriptional level. Emerging evidence suggests that altered regulation of miRNA may be …
transcriptional level. Emerging evidence suggests that altered regulation of miRNA may be …
[HTML][HTML] miR-34a and miR-15a/16 are co-regulated in non-small cell lung cancer and control cell cycle progression in a synergistic and Rb-dependent manner
N Bandi, E Vassella - Molecular cancer, 2011 - Springer
Background microRNAs (miRNAs) are small non-coding RNAs that are frequently involved
in carcinogenesis. Although many miRNAs form part of integrated networks, little information …
in carcinogenesis. Although many miRNAs form part of integrated networks, little information …
miR-194 suppresses metastasis of non-small cell lung cancer through regulating expression of BMP1 and p27kip1
X Wu, T Liu, O Fang, LJ Leach, X Hu, Z Luo - Oncogene, 2014 - nature.com
MicroRNAs (miRNAs) are increasingly implicated in regulating tumor malignance through
their capacity to coordinately repress expression of tumor-related genes. Here, we show that …
their capacity to coordinately repress expression of tumor-related genes. Here, we show that …
Clinical significance of miR-221 and its inverse correlation with p27Kip1 in hepatocellular carcinoma
X Fu, Q Wang, J Chen, X Huang, X Chen, L Cao… - Molecular biology …, 2011 - Springer
The aim of the present study is to explore possible role of miR-221 in the pathogenesis of
HCC. Matched HCC and adjacent non-cancerous samples were assayed for the expression …
HCC. Matched HCC and adjacent non-cancerous samples were assayed for the expression …
[HTML][HTML] Expression of miR-34c induces G2/M cell cycle arrest in breast cancer cells
C Achari, S Winslow, Y Ceder, C Larsson - BMC cancer, 2014 - Springer
Background MicroRNA-34 is a family of three miRNAs that have been reported to function as
tumor suppressor miRNAs and show decreased expression in various cancers. Here, we …
tumor suppressor miRNAs and show decreased expression in various cancers. Here, we …