in microparticle production. Microparticles can influence the development of thrombosis in
many ways. For example, microparticles provide a catalytic surface for the assembly of …

BACKGROUND: Anti-β2GP1 (β2-glycoprotein 1) antibodies are the primary pathogenic
antibody to promote thrombosis in antiphospholipid syndrome (APS), yet the underlying …

Platelets shed microparticles not only upon activation, but also upon ageing by an apoptosis-
like process (apoptosis-induced platelet microparticles, PM ap). While the activation-induced …

Exposure to phosphatidylserine (PS) tags dying and senescent cells for removal and
identifies activated platelets. In this study we followed the fate of PS-exposing platelets in the …

Essentials• β2 glycoprotein‐I (β 2 GPI) is a scavenger molecule that binds to microparticles
(MPs).• β 2 GPI expression on MPs was measured in systemic lupus erythematosus (SLE) …

Platelets play important roles in hemostasis. After vessel wall damage, platelets rapidly
adhere, aggregate, and secrete compounds that activate other platelets. This results in the …

Objective Antiphospholipid antibodies (aPL), especially those targeting β2‐glycoprotein I
(β2GPI), are well known to activate endothelial cells, monocytes, and platelets, with …

Immunoglobulins, antigens and complement can assemble to form immune complexes (IC).
ICs can be detrimental as they propagate inflammation in autoimmune diseases. Like ICs …

We recently reported that IgM antibody-related microparticles exist in some patients with
idiopathic thrombocytopenic purpura (ITP)[14]. In this study, we investigated the relationship …

Primary immune thrombocytopenia (ITP) and drug-induced thrombocytopenia (DITP) are
disorders caused primarily by the presence of anti-platelet auto-antibodies (Abs) …