Artery tertiary lymphoid organs contribute to innate and adaptive immune responses in advanced mouse atherosclerosis

SK Mohanta, C Yin, L Peng, P Srikakulapu… - Circulation …, 2014 - Am Heart Assoc
Tertiary lymphoid organs emerge in tissues in response to nonresolving inflammation.
Recent research characterized artery tertiary lymphoid organs in the aorta adventitia of aged …

Artery tertiary lymphoid organs: powerhouses of atherosclerosis immunity

C Yin, SK Mohanta, P Srikakulapu, C Weber… - Frontiers in …, 2016 - frontiersin.org
Artery tertiary lymphoid organs (ATLOs) are atherosclerosis-associated lymphoid
aggregates with varying degrees of complexity ranging from small T/B-cell clusters to well …

Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors

D Hu, SK Mohanta, C Yin, L Peng, Z Ma, P Srikakulapu… - Immunity, 2015 - cell.com
Tertiary lymphoid organs (TLOs) emerge during nonresolving peripheral inflammation, but
their impact on disease progression remains unknown. We have found in aged Apoe …

Adventitial inflammation and its interaction with intimal atherosclerotic lesions

M Akhavanpoor, S Wangler, CA Gleissner… - Frontiers in …, 2014 - frontiersin.org
The presence of adventitial inflammation in correlation with atherosclerotic lesions has been
recognized for decades. In the last years, several studies have investigated the relevance …

The lamina adventitia is the major site of immune cell accumulation in standard chow-fed apolipoprotein E–deficient mice

MPW Moos, N John, R Gräbner… - … , and vascular biology, 2005 - Am Heart Assoc
Objective—Cells of adaptive immunity have been implicated in atherogenesis. Though
substantial information is available on immune cells in atherosclerotic lesions of the lamina …

Lymphotoxin β receptor signaling promotes tertiary lymphoid organogenesis in the aorta adventitia of aged ApoE−/− mice

R Gräbner, K Lötzer, S Döpping, M Hildner… - Journal of Experimental …, 2009 - rupress.org
Atherosclerosis involves a macrophage-rich inflammation in the aortic intima. It is
increasingly recognized that this intimal inflammation is paralleled over time by a distinct …

Artery Tertiary Lymphoid Organs Control Multilayered Territorialized Atherosclerosis B-Cell Responses in Aged ApoE−/− Mice

P Srikakulapu, D Hu, C Yin, SK Mohanta… - … , and vascular biology, 2016 - Am Heart Assoc
Objective—Explore aorta B-cell immunity in aged apolipoprotein E-deficient (ApoE−/−) mice.
Approach and Results—Transcript maps, fluorescence-activated cell sorting …

The aorta can act as a site of naive CD4+ T-cell priming

N MacRitchie, G Grassia, J Noonan… - Cardiovascular …, 2020 - academic.oup.com
Aims Aortic adaptive immunity plays a role in atherosclerosis; however, the precise
mechanisms leading to T-cell activation in the arterial wall remain poorly understood …

Lymphocyte recruitment into the aortic wall before and during development of atherosclerosis is partially L-selectin dependent

E Galkina, A Kadl, J Sanders, D Varughese… - The Journal of …, 2006 - rupress.org
Atherosclerosis is an inflammatory disease of large arteries. Flow cytometry of aortic cell
suspensions showed that B and T lymphocytes and some macrophages and dendritic cells …

Lymphocytes and the adventitial immune response in atherosclerosis

KA Campbell, MJ Lipinski, AC Doran… - Circulation …, 2012 - Am Heart Assoc
Although much of the research on atherosclerosis has focused on the intimal accumulation
of lipids and inflammatory cells, there is an increasing amount of interest in the role of the …