Heme oxygenase 1 (HO-1, encoded by the HMOX1 gene) is the rate-limiting enzyme that
catalyzes heme degradation, and it has been reported to exert antioxidative effects …

The enzyme heme oxygenase-1 (HO-1) is pivotal in reproductive processes, particularly in
placental and vascular development. This study investigated the role of HO-1 and its …

Deletion of the heme oxygenase-1 (HO-1)(Hmox1) locus in mice results in intrauterine
lethality. The expression of the heme catabolizing enzyme encoded by this gene, namely …

Stress-induced downregulation of spermatogenesis remains poorly understood. This study
examined the induction of heme oxygenase-1 (HO-1), a carbon monoxide–generating …

Introduction Severe hypoxia exists in placentas during early pregnancy, with reoxygenation
during mid-gestation. Hypoxia-inducible factor-1α (Hif1α), an oxygen sensor, initiates …

Oxidative damage induced granulosa cells (GCs) apoptosis was considered as a significant
cause of compromised follicle quality, antioxidants therapy has emerged as a potential …

Citation Zenclussen ML, Jensen F, Rebelo S, El‐Mousleh T, Casalis PA, Zenclussen AC.
Heme oxygenase‐1 expression in the ovary dictates a proper oocyte ovulation, fertilization …

We previously confirmed that Nuclear factor erythroid 2-related factor-2 (Nrf2) and heme
oxygenase (HO-1) play synergistic roles in the pathogenesis of preeclampsia. To further …

Heat stress negatively affects reproduction in cattle by disrupting the normal function of
ovarian granulosa cells (GCs), ultimately leading to oxidative damage and cell death via …

Mesenchymal stem cells (MSCs) are involved in the pathogenesis of pre-eclampsia (PE).
Heme oxygenase (HMOX) protects against placental cytotoxic injuries associated with PE …