The leptin-leptin receptor system might be up-regulated in the airways of chronic obstructive
pulmonary disease (COPD). In bronchial biopsies obtained from normal subjects and …

Background: Chronic obstructive pulmonary disease (COPD) is characterised by an
abnormal inflammatory reaction of the lungs involving activation of epithelial cells. Leptin is …

Introduction: Chronic inflammation of the lung is a characteristic finding in chronic
obstructive pulmonary disease (COPD). Leptin is a pleiotropic cytokine thought to play a role …

The aim of the present study was to compare leptin and interleukin (IL)-6 expression in
patients and rat models with chronic obstructive pulmonary disease (COPD). Leptin and IL-6 …

Background: Weight loss is a clinically important risk factor indicating a poor prognosis in
chronic obstructive pulmonary disease (COPD). Leptin is an important regulator of food …

Chronic obstructive pulmonary disease (COPD) is a syndrome of chronic wasting, in part
associated with a chronic inflammatory response. The aim of this study was to investigate …

Leptin is a pleotropic hormone known to regulate a wide range of systemic functions, from
satiety to inflammation. Increasing evidence has shown that leptin and its receptor (ObR) are …

Leptin is an adipocyte-derived hormone, recognized as a critical mediator of the balance
between food intake and energy expenditure by signalling through its functional receptor …

BACKGROUND: The adipokine leptin is a potential new mediator for bronchial epithelial
homeostasis. Asthma is a chronic inflammatory disease characterized by airway remodeling …

Background Recent studies have provided evidence for a link between leptin and tumor
necrosis factor-alpha (TNF-α). Insulin-like growth factor I (IGF-I) mediates the metabolic …