Osteoarthritis (OA) is a disease of high prevalence that produces substantial morbidity and is
a leading cause of physical and psychological disability and expense, including time lost …

Osteoarthritis (OA) is a degenerative joint disease that progressively causes loss of joint
function and is the leading source of physical disability and impaired quality of life in …

Key Points Osteoarthritis (OA) is one of the most chronic health disorders in the western
world and becomes particularly common with advanced age. The joints most commonly …

The understanding of the pathogenesis of osteoarthritis (OA) has evolved considerably over
the past decade. Although the molecular causes of OA are still unknown, genetic …

Objectives As more has become known of the pathophysiology of osteoarthritis (OA),
evidence that inflammation plays a critical role in its development and progression has …

Osteoarthritis (OA) is defined by the American College of Rheumatology as a
“heterogeneous group of conditions that lead to joint symptoms and signs which are …

[Frontiers in Bioscience 4, d762-771, October 15, 1999] 762 FUTURE DIRECTIONS FOR
RESEARCH AND TREATMENT OF OSTEOARTHRITIS Charl Page 1 [Frontiers in Bioscience 4 …

This review is focused on advances in understanding the biology of joint homeostasis and
osteoarthritis (OA) pathogenesis mechanisms that have led to proof of concept studies on …

Introduction Osteoarthritis (OA) is one of the most common forms of arthritis. There is
accumulating evidence to suggest that OA is an inflammatory disease of the entire synovial …

Osteoarthritis (OA) has long been considered a “wear and tear” disease leading to loss of
cartilage. OA used to be considered the sole consequence of any process leading to …