A central challenge in systems biology and medical genetics is to understand how
interactions among genetic loci contribute to complex phenotypic traits and human diseases …

Genetic risk scores are an increasingly popular tool for summarizing the cumulative risk of a
set of Single Nucleotide Polymorphisms (SNPs) with disease. Typically only the set of the …

Genomic medicine aims to improve health using the individual genomic data of people to
inform care. While clinical utility of genomic medicine in many monogenic, Mendelian …

Editorial summary Genome-wide association studies have made strides in identifying
common variation associated with disease. The modest effect sizes preclude risk prediction …

The genetics and heredity of complex human traits have been studied for over a century.
Many genes have been implicated in these complex traits. Genome-wide association …

Various attempts have been made to predict the individual disease risk based on genotype
data from genome-wide association studies (GWAS). However, most studies only …

In complex trait genetics, the ability to predict phenotype from genotype is the ultimate
measure of our understanding of genetic architecture underlying the heritability of a trait. A …

Transitions from health to disease are characterized by dysregulation of biological networks
under the influence of genetic and environmental factors, often over the course of years to …

Polygenic risk scores (PRS) can provide useful information for personalized risk stratification
and disease risk assessment, especially when combined with non-genetic risk factors …

Polygenic scores (PGS) for coronary heart disease (CHD) are constructed using GWAS
summary statistics for CHD. However, pleiotropy is pervasive in biology and disease …