Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …

The early window of human embryogenesis is largely a black box for developmental
biologists. Here we probed the cellular diversity of 4–6 week human embryos when …

Ontogeny describes the emergence of complex multicellular organisms from single
totipotent cells. This field is particularly challenging in mammals, owing to the indeterminate …

Human limbs emerge during the fourth post-conception week as mesenchymal buds, which
develop into fully formed limbs over the subsequent months. This process is orchestrated by …

During post-implantation development of the mouse embryo, descendants of the inner cell
mass in the early epiblast transit from the naive to primed pluripotent state. Concurrently …

The house mouse (Mus musculus) is an exceptional model system, combining genetic
tractability with close evolutionary affinity to humans,. Mouse gestation lasts only 3 weeks …

Mammalian embryogenesis is characterized by rapid cellular proliferation and
diversification. Within a few weeks, a single-cell zygote gives rise to millions of cells …

Across the animal kingdom, gastrulation represents a key developmental event during which
embryonic pluripotent cells diversify into lineage-specific precursors that will generate the …

Gastrulation is the fundamental process in all multicellular animals through which the basic
body plan is first laid down,,–. It is pivotal in generating cellular diversity coordinated with …

Understanding how gene regulatory networks control the progressive restriction of cell fates
is a long-standing challenge. Recent advances in measuring gene expression in single cells …