The blastocyst (the early mammalian embryo) forms all embryonic and extra-embryonic
tissues, including the placenta. It consists of a spherical thin-walled layer, known as the …

Organogenesis involves integration of diverse cell types; dysregulation of cell-type-specific
gene networks results in birth defects, which affect 5% of live births. Congenital heart defects …

Cell competition—the sensing and elimination of less fit 'loser'cells by neighbouring
'winner'cells—was first described in Drosophila. Although cell competition has been …

Among primates, humans display a unique trajectory of development that is responsible for
the many traits specific to our species. However, the inaccessibility of primary human and …

We present a multiomic cell atlas of human lung development that combines single-cell RNA
and ATAC sequencing, high-throughput spatial transcriptomics, and single-cell imaging …

The maturation of single-cell transcriptomic technologies has facilitated the generation of
comprehensive cellular atlases from whole embryos,,–. A majority of these data, however …

Molecular approaches to understanding the functional circuitry of the nervous system
promise new insights into the relationship between genes, brain and behaviour. The cellular …

Integrative analysis of multi-omics layers at single cell level is critical for accurate dissection
of cell-to-cell variation within certain cell populations. Here we report scCAT-seq, a …

It is becoming increasingly clear that the shape of the genome importantly influences
transcription regulation. Pluripotent stem cells such as embryonic stem cells were recently …

Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …