Enhancing AMPA to NMDA throughput as a convergent mechanism for antidepressant action
J Du, R Machado-Vieira, S Maeng… - Drug discovery today …, 2006 - Elsevier
In this article, we first review current knowledge of the AMPA and NMDA glutamate
receptors, their physiological properties and functions and their regulation by signaling …
receptors, their physiological properties and functions and their regulation by signaling …
The role of glutamate in mood disorders: results from the ketamine in major depression study and the presumed cellular mechanism underlying its antidepressant …
S Maeng, CA Zarate Jr - Current psychiatry reports, 2007 - Springer
In this article, we first review a study showing that the N-methyl-d-aspartate (NMDA) receptor
antagonist ketamine leads to rapid, robust, and relatively sustained antidepressant effects in …
antagonist ketamine leads to rapid, robust, and relatively sustained antidepressant effects in …
Rapid-onset antidepressant efficacy of glutamatergic system modulators: the neural plasticity hypothesis of depression
Depression is a devastating psychiatric disorder widely attributed to deficient
monoaminergic signaling in the central nervous system. However, most clinical …
monoaminergic signaling in the central nervous system. However, most clinical …
The NMDA receptor as a therapeutic target in major depressive disorder
C Pittenger, G Sanacora… - CNS & Neurological …, 2007 - ingentaconnect.com
Ample evidence indicates that glutamate homeostasis and neurotransmission are disrupted
in major depressive disorder; but the nature of this disruption and the mechanisms by which …
in major depressive disorder; but the nature of this disruption and the mechanisms by which …
Clinical overview of NMDA-R antagonists and clinical practice
PA Davoudian, ST Wilkinson - Advances in Pharmacology, 2020 - Elsevier
Depression represents one of the most common and debilitating mental illnesses in the
world today. Despite this pressing issue, the majority treatments for depression give patients …
world today. Despite this pressing issue, the majority treatments for depression give patients …
Cell-type specific modulation of NMDA receptors triggers antidepressant actions
Both the NMDA receptor (NMDAR) positive allosteric modulator (PAM), and antagonist, can
exert rapid antidepressant effects as shown in several animal and human studies. However …
exert rapid antidepressant effects as shown in several animal and human studies. However …
New targets for rapid antidepressant action
Current therapeutic options for major depressive disorder (MDD) and bipolar disorder (BD)
are associated with a lag of onset that can prolong distress and impairment for patients, and …
are associated with a lag of onset that can prolong distress and impairment for patients, and …
A role for AMPA receptors in mood disorders
A Alt, ES Nisenbaum, D Bleakman, JM Witkin - Biochemical pharmacology, 2006 - Elsevier
Major antidepressant agents increase synaptic levels of monoamines. Although the
monoamine hypothesis of depression remains a cornerstone of our understanding of the …
monoamine hypothesis of depression remains a cornerstone of our understanding of the …
Importance of exploring n-methyl-d-aspartate (NMDA) as a future perspective target in depression
Major depressive disorder (MDD) is a serious and complex mental illness. Currently, many
antidepressants are available in the market for the treatment of MDD. However, these agents …
antidepressants are available in the market for the treatment of MDD. However, these agents …
NMDA receptor activation-dependent antidepressant-relevant behavioral and synaptic actions of ketamine
Ketamine is a well-characterized NMDA receptor (NMDAR) antagonist, although the
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …
relevance of this pharmacology to its rapid (within hours of administration) antidepressant …