Hepatic fibrosis is a pathological lesion, characterized by the progressive accumulation of
extracellular matrix (ECM) in the perisinusoidal space and it is a major problem in chronic …

Hepatic fibrosis is a wound-healing process that occurs when the liver is injured chronically.
Hepatic stellate cells (HSC) are responsible for the excess production of extracellular matrix …

Liver fibrosis is a reversible wound-healing process aimed at maintaining organ integrity,
and presents as the critical pre-stage of liver cirrhosis, which will eventually progress to …

Hepatic fibrosis is an outcome of many chronic liver diseases, such as viral and autoimmune
hepatitis, and of alcohol consumption and biliary obstruction. Prolonged liver injury results in …

Liver fibrosis (LF) occurs as a result of persistent liver injury and can be defined as a
pathologic, chronic, wound‐healing process in which functional parenchyma is …

Hepatic fibrosis is a reversible wound healing response characterized by accumulation of
extracellular matrix (ECM), or" scar," that follows chronic but not self-limited liver disease …

Following chronic liver injury of any etiology, there is progressive fibrosis. To date, removing
the causative agent is the only effective therapy to stop or even reverse liver fibrosis …

Hepatic fibrosis is a wound‐healing response to chronic liver injury, which if persistent leads
to cirrhosis and liver failure. Exciting progress has been made in understanding the …

The liver is a critical system for metabolism in human beings, which plays an essential role
in an abundance of physiological processes and is vulnerable to endogenous or exogenous …

Highlights•Hepatic stellate cell activation/myofibroblast transition is the main driver of liver
fibrosis.•Paracrine signals from adjacent cells induce stellate cell activation.•Alteration in …