[PDF][PDF] In vivo preclinical imaging

J Comley - Drug Discovery, 2011 - ddw-online.com
In vivo imaging is increasingly deployed across the drug development process, with
applicability in target identification, compound optimisation and pre-Phase I studies. In vivo …

[图书][B] In vivo imaging in drug discovery

JL Kristensen, MM Herth - 2017 - books.google.com
At an early stage of the drug discovery process, it is important to advance the evaluation of
potential drug candidates from in vitro to in vivo investigations. The initial development of …

Imaging in drug discovery and early clinical trials

M Rudin, EE Kim - 2007 - Soc Nuclear Med
In recent years, drug discovery has evolved into a distinct branch of science. The impact of
genomics on biomedical research and the development of efficient technology platforms …

[HTML][HTML] In vivo Imaging in Pharmacological Research

N Beckmann, IA Kaltashov, AD Windhorst - Frontiers in pharmacology, 2017 - frontiersin.org
The discovery and development of a biologically active molecule with therapeutic properties
is an increasingly complex task, highly unpredictable at the early stages and frequently …

Technologies: preclinical imaging for drug development

PM Matthews, R Coatney, H Alsaid, B Jucker… - Drug Discovery Today …, 2013 - Elsevier
Preclinical imaging with magnetic resonance imaging (MRI), computerised tomography
(CT), ultrasound (US), positron emission tomography (PET) or single-photon emission …

[HTML][HTML] What can you see with imaging in pharmaceutical research?

ZR Lu - Molecular Pharmaceutics, 2006 - ACS Publications
The pharmaceutical research community has had a longstanding guideline that for
experimental therapeutic preclinical studies at least six animals are required for each data …

Why Preclinical Imaging and What Will Happen in the Future?

R Solgi, PE Sharif - Frontiers in Biomedical Technologies, 2021 - scholar.archive.org
Small laboratory animals such as mice are being used to understand more about the biology
of human system. This would create a setup where more information is extracted from …

Preclinical imaging: an essential ally in modern biosciences

L Cunha, I Horvath, S Ferreira, J Lemos… - Molecular diagnosis & …, 2014 - Springer
Translational research is changing the practice of modern medicine and the way in which
health problems are approached and solved. The use of small-animal models in basic and …

[PDF][PDF] Medical imaging in drug discovery, Part I

AJ Sinskey, SN Finkelstein, SM Cooper - PharmaGenomics. March/April, 2004 - mit.edu
While economic, scientific and regulatory questions still need to be answered, imaging
technologies have the potential to increase efficiencies in many areas of drug research. This …

Multimodality imaging: novel pharmacological applications of reporter systems

A Stell, S Belcredito, B Ramachandran… - The Quarterly Journal …, 2007 - search.proquest.com
The development of novel drugs is a lengthy process requiring years of preclinical research
and many steps indispensable to ensure that the molecule of interest can be administered to …