The idea of individualizing therapies to obtain optimal clinical results is not new but has only
recently been applied to kidney diseases. Nonetheless, kidney disorders present a variety of …

Research in the field of nephrology continues to improve our understanding of the
mechanisms that promote and drive kidney disease, including how human genetic variation …

Chronic kidney disease (CKD) has shown an increasing prevalence in the last century. CKD
encompasses a poor prognosis related to a remarkable number of comorbidities, and many …

The prevalence of renal diseases is rising and reaching 5–15% of the adult population.
Renal damage is associated with disturbances of body homeostasis and the loss of …

The kidney is a complex organ responsible for maintaining multiple aspects of homeostasis
in the human body. The combination of distinct, yet interrelated, molecular functions across …

The goal of “precision medicine” is to characterize diseases based on the underlying
molecular biology, in order to identify specific biomarkers and therapeutic targets that will …

Numerous clinical trials are currently evaluating new strategies to halt the progression of
renal damage in patients with chronic kidney diseases (CKDs). Unfortunately, none of them …

Individual drug response variability is a recognized phenomenon in clinical practice. It is
time to implement novel approaches that take into account this response variability in the …

As opposed to diseases such as cancer, autoimmune disease, and diabetes, identifying
drugs to treat CKD has proven significantly more challenging. Over the past 2 decades, new …

Clinical trials in nephrology have focused on achieving targets, supplementing deficiencies,
and correcting excesses in order to improve patient outcomes. The majority of interventions …