Activators and inhibitors of NRF2: a review of their potential for clinical development
N Robledinos-Antón… - Oxidative medicine …, 2019 - Wiley Online Library
The transcription factor NRF2 (nuclear factor erythroid 2‐related factor 2) triggers the first
line of homeostatic responses against a plethora of environmental or endogenous …
line of homeostatic responses against a plethora of environmental or endogenous …
Modulation of NRF2: biological dualism in cancer, targets and possible therapeutic applications
M Gallorini, S Carradori, E Panieri, M Sova… - Antioxidants & Redox …, 2024 - liebertpub.com
Significance: The nuclear factor erythroid 2-related factor 2 (NRF2)-Kelch-like ECH-
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
associated protein 1 (KEAP1) system is a master regulator of redox homeostasis and cell …
Potential applications of NRF2 inhibitors in cancer therapy
E Panieri, L Saso - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
The NRF2/KEAP1 pathway represents one of the most important cell defense mechanisms
against exogenous or endogenous stressors. Indeed, by increasing the expression of …
against exogenous or endogenous stressors. Indeed, by increasing the expression of …
An update of Nrf2 activators and inhibitors in cancer prevention/promotion
F Pouremamali, A Pouremamali, M Dadashpour… - Cell Communication and …, 2022 - Springer
Abstract NF-E2-related factor 2 (Nrf2) protein is a basic-region leucine zipper transcription
factor that defends against endogenous or exogenous stressors. By inducing several …
factor that defends against endogenous or exogenous stressors. By inducing several …
The rise of antioxidant signaling—the evolution and hormetic actions of Nrf2
J Maher, M Yamamoto - Toxicology and applied pharmacology, 2010 - Elsevier
Organisms have evolved sophisticated and redundant mechanisms to manage oxidative
and electrophilic challenges that arise from internal metabolism or xenobiotic challenge for …
and electrophilic challenges that arise from internal metabolism or xenobiotic challenge for …
The dual roles of NRF2 in cancer
S Menegon, A Columbano, S Giordano - Trends in molecular medicine, 2016 - cell.com
NRF2 has been traditionally considered as a tumor suppressor because its cytoprotective
functions are deemed to be the main cellular defense mechanism against exogenous and …
functions are deemed to be the main cellular defense mechanism against exogenous and …
[HTML][HTML] Controversy about pharmacological modulation of Nrf2 for cancer therapy
Conventional anticancer therapies such as radiotherapy and chemotherapies are
associated with oxidative stress generating reactive oxygen species (ROS) and reactive …
associated with oxidative stress generating reactive oxygen species (ROS) and reactive …
Design and development of Nrf2 modulators for cancer chemoprevention and therapy: A review
A major cell defense mechanism against oxidative and xenobiotic stress is mediated by the
Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many …
Nrf2/Keap1 signaling pathway. The Nrf2/Keap1 pathway regulates gene expression of many …
Potential applications of NRF2 modulators in cancer therapy
The nuclear factor erythroid 2-related factor 2 (NRF2)–Kelch-like ECH-associated protein 1
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
(KEAP1) regulatory pathway plays an essential role in protecting cells and tissues from …
Nuclear factor erythroid 2-related factor 2 in regulating cancer metabolism
Significance: Nuclear factor erythroid 2 (NFE2)-related factor 2 (NFE2L2, or NRF2) is a
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …
transcription factor predominantly affecting the expression of antioxidant genes. NRF2 plays …