Molecular mechanisms of Nrf2 regulation and how these influence chemical modulation for disease intervention
Nrf2 (nuclear factor erytheroid-derived-2-like 2) transcriptional programmes are activated by
a variety of cellular stress conditions to maintain cellular homoeostasis. Under non-stress …
a variety of cellular stress conditions to maintain cellular homoeostasis. Under non-stress …
[HTML][HTML] Modulation of NRF2 signaling pathway by nuclear receptors: implications for cancer
Abstract Nuclear factor-erythroid 2 p45-related factor 2 (NRF2, also known as Nfe2l2) plays
a critical role in regulating cellular defense against electrophilic and oxidative stress by …
a critical role in regulating cellular defense against electrophilic and oxidative stress by …
Nrf2 in cancers: A double‐edged sword
S Wu, H Lu, Y Bai - Cancer medicine, 2019 - Wiley Online Library
Abstract The Nrf2/Keap1 pathway is an important signaling cascade responsible for the
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …
resistance of oxidative damage induced by exogenous chemicals. It maintains the redox …
Modulating NRF2 in disease: timing is everything
M Dodson, MR de la Vega… - Annual review of …, 2019 - annualreviews.org
The transcription factor nuclear factor erythroid 2 (NF-E2)-related factor 2 (NRF2) is a central
regulator of redox, metabolic, and protein homeostasis that intersects with many other …
regulator of redox, metabolic, and protein homeostasis that intersects with many other …
“NRF2 addiction” in lung cancer cells and its impact on cancer therapy
Nuclear factor erythroid 2-like factor 2 (NRF2) is a master regulator of the antioxidant
enzymes and the detoxification proteins that play major roles in redox homeostasis …
enzymes and the detoxification proteins that play major roles in redox homeostasis …
NRF2 as a regulator of cell metabolism and inflammation in cancer
Nuclear factor erythroid 2‐related factor 2 (NRF2) is a master transcriptional regulator of
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …
genes whose products defend our cells for toxic and oxidative insults. Although NRF2 …
[HTML][HTML] Perspectives of the Nrf-2 signaling pathway in cancer progression and therapy
The Nuclear factor erythroid2-related factor2 (Nrf2), a master regulator of redox
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …
homoeostasis, is a key transcription factor regulating a wide array of genes for antioxidant …
Transcriptional regulation by Nrf2
Significance: Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
coordinates the basal and stress-inducible activation of a vast array of cytoprotective genes …
NRF2 and the ambiguous consequences of its activation during initiation and the subsequent stages of tumourigenesis
H Robertson, AT Dinkova-Kostova, JD Hayes - Cancers, 2020 - mdpi.com
Simple Summary Transcription factor NRF2 controls expression of antioxidant and
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …
detoxification genes. Normally, the activity of NRF2 is tightly controlled in the cell, and is …
The complexity of the Nrf2 pathway: beyond the antioxidant response
The NF-E2-related factor 2 (Nrf2)-mediated signalling pathway provides living organisms an
efficient and pivotal line of defensive to counteract environmental insults and endogenous …
efficient and pivotal line of defensive to counteract environmental insults and endogenous …