Dimethyl fumarate (DMF) is an electrophilic compound previously called BG-12 and
marketed under the name Tecfidera®. It was approved in 2013 by the US Food and Drug …

Nrf2 acts as a sensor of oxidative or electrophilic stress and prevents genome instability. The
activation of Nrf2 signaling induces ARE-dependent expression of detoxifying and …

The liver executes versatile functions and is the chief organ for metabolism of
toxicants/xenobiotics. Hepatocellular carcinoma (HCC) is the most common primary liver …

In response to oxidative stress, the transcription factor NF-E2-related factor 2 (Nrf2) controls
the fate of cells through transcriptional upregulation of antioxidant response element (ARE) …

The transcription factor NF-E2 p45-related factor 2 (NRF2; encoded by NFE2L2) plays a
critical role in the maintenance of cellular redox and metabolic homeostasis, as well as the …

The transcription factor Nrf2 (nuclear factor‐erythroid 2 p45‐related factor 2) functions at the
interface of cellular redox and intermediary metabolism. Nrf2 target genes encode …

The imbalance between reactive oxygen species (ROS) production and clearance causes
oxidative stress and ROS, which play a central role in regulating cell and tissue physiology …

NRF2 serves as the master regulator of oxidative stress resistance in mammalian cells.
Although NRF2 activation decreases tumorigenic events in normal cells, accumulating …

The nuclear factor erythroid-derived 2 (NF-E2)-related factor 2 (Nrf2) is a transcription factor
well-known for its function in controlling the basal and inducible expression of a variety of …

Chemoresistance represents the main obstacle to cancer treatment with both conventional
and targeted therapy. Beyond specific molecular alterations, which can lead to targeted …