Many studies of chemopreventive drugs have suggested that their beneficial effects on
suppression of carcinogenesis and many other chronic diseases are mediated through …

Increased reactive oxygen species production and oxidative stress have been implicated in
the pathogenesis of numerous neurodegenerative conditions including among others …

Abstract The Cancer Genome Atlas catalogued alterations in the Kelch-like ECH-associated
protein 1 and nuclear factor erythroid 2–related factor 2 (NRF2) signaling pathway in 6.3% of …

Nrf2, a redox sensitive transcription factor, plays a pivotal role in redox homeostasis during
oxidative stress. Nrf2 is sequestered in cytosol by an inhibitory protein Keap1 which causes …

Nuclear factor erythroid 2-related factor 2 (Nrf2) is an essential component of cellular
defense against a vast variety of endogenous and exogenous insults, including oxidative …

The NRF2–KEAP1 system is a fundamental component of the cellular response that controls
a great variety of transcriptional targets that are mainly involved in the regulation of redox …

Tumors contain a distinct small subpopulation of cells that possess stem cell‐like
characteristics. These cells have been called cancer stem cells (CSCs) and are thought to …

Organisms are continually exposed to exogenous and endogenous sources of reactive
oxygen species (ROS) and other oxidants that have both beneficial and deleterious effects …

Breast cancer is the second leading cancer among all types of cancers. It accounts for 12%
of the total cases of cancers. The complex and heterogeneous nature of breast cancer …

The Kelch‐like ECH‐associated protein 1/nuclear factor erythroid‐derived 2‐like 2 (KEAP 1‐
NRF 2) system is a pivotal defense mechanism against oxidative and electrophilic stress …