Abstract CRISPR-Cas (Clustered, Regularly Interspaced, Short Palindromic Repeats–
CRISPR-associated (Cas)) RNA guided endonuclease has emerged as the most effective …

The simple applicability and facile target programming of the CRISPR/Cas9-system abolish
the major boundaries of previous genome editing tools, making it the tool of choice for …

With the technology's accessibility and ease of use, CRISPR has been employed widely in
many different organisms and experimental settings. As a result, thousands of publications …

The CRISPR-Cas system facilitates highly efficient genome editing; thus, it has been applied
in many research fields such as biological science, medicine, and gene therapy. However …

Following the type II CRISPR-Cas9 system, type V CRISPR-Cpf1 endonucleases have been
found to be applicable for genome editing in various organisms in vivo. However, there are …

The recent advance in genome engineering technologies based on CRISPR/Cas9 system is
enabling people to systematically understand genomic functions. A short RNA string (the …

Precise nucleic acid editing technologies have facilitated the research of cellular function
and the development of novel therapeutics, especially the current programmable nucleases …

CRISPR and CRISPR-associated (Cas) proteins, which in nature comprise the RNA-based
adaptive immune system in bacteria and archaea, have emerged as particularly powerful …

CRISPR-Cas9 is quickly revolutionizing the way we approach gene therapy. CRISPR-Cas9
is a complexed, two-component system using a short guide RNA (gRNA) sequence to direct …

The CRISPR-Cas9 RNA-guided DNA endonuclease has contributed to an explosion of
advances in the life sciences that have grown from the ability to edit genomes within living …