A pre-existing T cell-inflamed tumor microenvironment has prognostic utility and also can be
predictive for response to contemporary cancer immunotherapies. The generation of a …

Immunotherapies have revolutionized the treatment paradigms of various types of cancers.
However, most of these immunomodulatory strategies focus on harnessing adaptive …

A major subset of patients with advanced solid tumors show a spontaneous T cell-inflamed
tumor microenvironment, which has prognostic import and is associated with clinical …

The majority of current cancer immunotherapy strategies target and potentiate antitumor
adaptive immune responses. Unfortunately, the efficacy of these treatments has been limited …

The innate immune sensing pathways play critical roles in the defense against pathogen
infection, but their roles in cancer immunosurveillance and cancer therapies are less …

The immune system evolved for adequate surveillance and killing of pathogens while
minimizing host damage, such as due to chronic or exaggerated inflammation and …

Spontaneous T cell responses against tumors occur frequently and have prognostic value in
patients. The mechanism of innate immune sensing of immunogenic tumors leading to …

Passive immunotherapy, including adoptive T-cell therapy and antibody therapy, has shown
encouraging results in cancer treatment lately. However, active immunotherapy of solid …

The first generation of immune checkpoint inhibitors (anti-CTLA-4 and anti-PD-1/PD-L1)
targeted natural immune homeostasis pathways, co-opted by cancers, to drive anti-tumor …

New therapies that promote antitumour immunity have been recently developed. Most of
these immunomodulatory approaches have focused on enhancing T-cell responses, either …