Arf induces p53-dependent and-independent antiproliferative genes
ML Kuo, EJ Duncavage, R Mathew, W Den Besten… - Cancer Research, 2003 - AACR
The tumor suppressor p19Arf (p14ARF in humans), encoded by the Ink4a/Arf locus, is
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
mutated, deleted, or silenced in many forms of cancer. p19Arf induces growth arrest by …
p53-Dependent and-independent functions of the Arf tumor suppressor
CJ Sherr, D Bertwistle, W Den Besten… - Cold Spring Harbor …, 2005 - symposium.cshlp.org
Abstract The Ink4a-Arf locus encodes two closely wedded tumor suppressor proteins (p16
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
Ink4a and p19 Arf) that inhibit cell proliferationby activating Rb and p53, respectively. With …
p14ARF induces G2 arrest and apoptosis independently of p53 leading to regression of tumours established in nude mice
B Eymin, C Leduc, JL Coll, E Brambilla, S Gazzeri - Oncogene, 2003 - nature.com
Until recently, the ability of ARF (human p14 ARF, murine p19 ARF) tumour-suppressor
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
protein, encoded by the INK4A/ARF locus, to inhibit cell growth in response to various stimuli …
Human p14ARF-mediated cell cycle arrest strictly depends on intact p53 signaling pathways
HO Weber, T Samuel, P Rauch, JO Funk - Oncogene, 2002 - nature.com
The tumor suppressor ARF is transcribed from the INK4a/ARF locus in partly overlapping
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
reading frames with the CDK inhibitor p16 Ink4a. ARF is able to antagonize the MDM2 …
Tumor Spectrum in ARF-deficient Mice
T Kamijo, S Bodner, E van de Kamp, DH Randle… - Cancer research, 1999 - AACR
The p19ARF product of the INK4a/ARF locus is induced in response to potentially oncogenic
hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2 …
hyperproliferative signals and activates p53 by interfering with its negative regulator, Mdm2 …
Functional and physical interactions of the ARF tumor suppressor with p53 and Mdm2
T Kamijo, JD Weber, G Zambetti… - Proceedings of the …, 1998 - National Acad Sciences
The INK4a-ARF locus encodes two proteins, p16INK4a and p19ARF, that restrain cell
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
growth by affecting the functions of the retinoblastoma protein and p53, respectively …
p19ARF prevents G1 cyclin-dependent kinase activation by interacting with MDM2 and activating p53 in mouse fibroblasts
K Kurokawa, T Tanaka, J Kato - Oncogene, 1999 - nature.com
Abstract p19 ARF encoded by the INK4a tumor suppressor gene locus functions upstream of
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
p53 to induce cell cycle arrest. p19 ARF can interact with MDM2 and p53 in cells ectopically …
E2F and Ras Synergize in Transcriptionally Activating p14ARF Expression
E Berkovich, Y Lamed, D Ginsberg - Cell Cycle, 2003 - Taylor & Francis
The INK4a/ARF locus, which is frequently inactivated in human tumors, encodes two distinct
tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by …
tumor suppressive proteins, ARF and p16INK4a. ARF stabilizes and activates p53 by …
ATM activity contributes to the tumor-suppressing functions of p14ARF
Abstract P14/p19 ARF (ARF) plays a major role in the activation of p53 by oncogenic
signals. The biochemical basis of this has not been fully elucidated. We report here that …
signals. The biochemical basis of this has not been fully elucidated. We report here that …
Multiple interacting domains contribute to p14ARF mediated inhibition of MDM2
PA Clark, S Llanos, G Peters - Oncogene, 2002 - nature.com
The small basic protein p14 ARF, encoded by one of the alternative transcripts from the
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …
human INK4A/ARF locus, interferes with MDM2-mediated ubiquitination of the p53 tumour …