p19ARF is dispensable for oncogenic stress-induced p53-mediated apoptosis and tumor suppression in vivo
D Tolbert, X Lu, C Yin, M Tantama… - Molecular and cellular …, 2002 - Am Soc Microbiol
Recent studies have shown the p19 ARF tumor suppressor to be involved in the response to
oncogenic stress by regulating the activity of p53. This response is mediated by …
oncogenic stress by regulating the activity of p53. This response is mediated by …
[HTML][HTML] Dual role of the alternative reading frame ARF protein in cancer
The CDKN2a/ARF locus expresses two partially overlapping transcripts that encode two
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
distinct proteins, namely p14ARF (p19Arf in mouse) and p16INK4a, which present no …
[HTML][HTML] CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53
The INK4a locus on chromosome 9p21 encodes two structurally distinct tumor suppressor
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
proteins, p16 INK4a and the alternative reading frame protein, ARF (p19 ARF in mouse and …
p14ARF regulates E2F activity
SL Mason, OÈ Loughran, NB La Thangue - Oncogene, 2002 - nature.com
The ARF protein product of the ink4a/arf locus is induced by a variety of oncogenic signals.
ARF facilitates growth arrest through the p53 pathway by hindering the down-regulation of …
ARF facilitates growth arrest through the p53 pathway by hindering the down-regulation of …
Cooperativity of p19ARF, Mdm2, and p53 in murine tumorigenesis
L Moore, S Venkatachalam, H Vogel, JC Watt, CL Wu… - Oncogene, 2003 - nature.com
The p19 ARF gene product responds to oncogenic stresses by interfering with the inhibitory
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …
effects of Mdm2 on p53, thus enhancing p53 activity and its antiproliferative functions. The …
p19ARF-induced p53-independent apoptosis largely occurs through BAX
H Suzuki, M Kurita, K Mizumoto, I Nishimoto… - Biochemical and …, 2003 - Elsevier
Combined disruption of the ARF gene and the p53 gene causes mouse predisposition to
tumors of a wider variety and at a higher frequency than disruption of the p53 gene …
tumors of a wider variety and at a higher frequency than disruption of the p53 gene …
Loss of p21 disrupts p14ARF-induced G1 cell cycle arrest but augments p14ARF-induced apoptosis in human carcinoma cells
PG Hemmati, G Normand, B Verdoodt, C von Haefen… - Oncogene, 2005 - nature.com
The human INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
INK4a and p14 ARF (p19 ARF in the mouse), which are frequently inactivated in human …
Human ARF binds E2F1 and inhibits its transcriptional activity
B Eymin, L Karayan, P Séité, C Brambilla, E Brambilla… - Oncogene, 2001 - nature.com
The INK4a/ARF locus which is frequently inactivated in human tumours encodes two
different tumour suppressive proteins, p16 INK4a and ARF. p16 INK4a is a major component …
different tumour suppressive proteins, p16 INK4a and ARF. p16 INK4a is a major component …
Adenovirus-mediated overexpression of p14ARF induces p53 and Bax-independent apoptosis
PG Hemmati, B Gillissen, C von Haefen, J Wendt… - Oncogene, 2002 - nature.com
The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …
p16 INK4a and p14 ARF, which are frequently inactivated in human cancer. Whereas p16 …
Human tumor suppressor ARF impedes S-phase progression independent of p53
WG Yarbrough, M Bessho, A Zanation, JE Bisi, Y Xiong - Cancer research, 2002 - AACR
Using alternative reading frames, the human ARF-INK4a locus encodes two unrelated
proteins that both function in tumor suppression. p16INK4a maintains the retinoblastoma …
proteins that both function in tumor suppression. p16INK4a maintains the retinoblastoma …