Arf tumor suppressor promoter monitors latent oncogenic signals in vivo
F Zindy, RT Williams, TA Baudino… - Proceedings of the …, 2003 - National Acad Sciences
Induction of the Arf tumor suppressor gene by elevated thresholds of mitogenic signals
activates a p53-dependent transcriptional response that triggers either growth arrest or …
activates a p53-dependent transcriptional response that triggers either growth arrest or …
Stabilization of p53 by p14ARF without relocation of MDM2 to the nucleolus
S Llanos, PA Clark, J Rowe, G Peters - Nature cell biology, 2001 - nature.com
The alternative product of the human INK4a/ARF locus, p14 ARF, has the potential to act as
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
a tumour suppressor by binding to and inhibiting the p53 antagonist MDM2. Current models …
ARF promotes MDM2 degradation and stabilizes p53: ARF-INK4a locus deletion impairs both the Rb and p53 tumor suppression pathways
The INK4a-ARF locus encodes two unrelated proteins that both function in tumor
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
suppression. p16 INK4a binds to and inhibits the activity of CDK4 and CDK6, and ARF …
p53-independent functions of the p19ARF tumor suppressor
The p19ARF tumor suppressor antagonizes Mdm2 to induce p53-dependent cell cycle
arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop …
arrest. Individual TKO (triple knock out) mice nullizygous for ARF, p53, and Mdm2 develop …
A major functional difference between the mouse and human ARF tumor suppressor proteins
Suppression of tumorigenesis is considerably more stringent in the human than in the much
shorter lived mouse species, and the reasons for this difference are poorly understood. We …
shorter lived mouse species, and the reasons for this difference are poorly understood. We …
Enforced expression of p14ARF induces p53-dependent cell cycle arrest but not apoptosis
Expression of the p14ARF tumour suppressor is induced by hyperproliferative signals
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …
produced by RAS, MYC and other oncogenes. p14ARF quenches inappropriate mitogenic …
p53: only ARF the story
AC Lloyd - Nature Cell Biology, 2000 - nature.com
p53: only ARF the story | Nature Cell Biology Skip to main content Thank you for visiting
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Two arginine rich domains in the p14ARF tumour suppressor mediate nucleolar localization
The INK4a/ARF locus encodes two distinct tumour suppressors, p16 INK4a and p14ARF,
that regulate cell cycle progression via the pRB and p53 pathways, respectively. The ARF …
that regulate cell cycle progression via the pRB and p53 pathways, respectively. The ARF …
The ARF tumour suppressor
The ARF tumour suppressor is a product of the INK4a/ARF locus; a sequence that is
frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical …
frequently altered in human cancer. ARF is upregulated by oncogenic stimuli and is a critical …
Non-canonical functions of the ARF tumor suppressor in development and tumorigenesis
N Lagopati, K Belogiannis, A Angelopoulou… - Biomolecules, 2021 - mdpi.com
P14ARF (ARF; Alternative Reading Frame) is an extensively characterized tumor
suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis …
suppressor which, in response to oncogenic stimuli, mediates cell cycle arrest and apoptosis …