One of the outstanding fundamental questions in cancer cell biology concerns how cells
coordinate cellular growth (or macromolecular synthesis) with cell cycle progression and …

Ionizing radiation leads to rapid stabilization and activation of the p53 tumor suppressor.
Previous reports demonstrate that murine p19ARF cooperates with p53 in the cellular …

The Arf tumor suppressor protein inhibits cell proliferation through both p53-dependent and-
independent mechanisms. Two rat monoclonal antibodies raised against a peptide …

The human INK4a gene locus encodes two structurally unrelated tumor suppressor proteins,
p16 INK4a and p14 ARF. Although primarily proposed to require a functional p53· Mdm-2 …

Ectopic expression of oncogenes such as Ras induces expression of p19Arf, which, in turn,
activates p53 and growth arrest. Here, we used a multistage model of squamous cell …

The ARF/MDM2/p53 pathway is a principal defense mechanism to protect the organism from
uncontrolled effects of deregulated oncogenes. Oncogenes activate ARF, which interacts …

Inactivation of the P16 (INK4A)/retinoblastoma (RB) or TP53 biochemical pathway is
frequent event in most human cancers. Recent evidence has shown that P14ARF binds to …

p14ARF, the alternative product from the human INK4a/ARF locus, is one of the major
targets for alterations in the development of human cancers. Overexpression of p14ARF …

p14 ARF, a product of the INK4A/ARF locus, induces p53 upregulation by neutralizing the
effects of MDM2, a transcriptional target of p53 that antagonizes its function. Here we report …

Abstract The Ink4/Arf locus encodes two tumour-suppressor proteins, p16 Ink4a and p19 Arf,
that govern the antiproliferative functions of the retinoblastoma and p53 proteins …