Association of p14ARF with the p120E4FTranscriptional Repressor Enhances Cell Cycle Inhibition
H Rizos, E Diefenbach, P Badhwar, S Woodruff… - Journal of Biological …, 2003 - ASBMB
The p14 ARF tumor suppressor is a key regulator of cellular proliferation and is frequently
inactivated in human cancer. This tumor suppressor functions in the p53 and pRb cell cycle …
inactivated in human cancer. This tumor suppressor functions in the p53 and pRb cell cycle …
Human p14Arf: an exquisite sensor of morphological changes and of short-lived perturbations in cell cycle and in nucleolar function
T David-Pfeuty, Y Nouvian-Dooghe - Oncogene, 2002 - nature.com
Abstract The human Ink4a/Arf tumor suppressor locus encodes two distinct products: p16
Ink4a which prevents phosphorylation and inactivation of the retinoblastoma protein and …
Ink4a which prevents phosphorylation and inactivation of the retinoblastoma protein and …
Aberrant expression of p14ARF in human cancers: A new biomarker?
K Inoue, EA Fry - Tumor and Microenvironment, 2018 - journals.lww.com
The ARF and INK4a genes are located on the same CDKN2a locus, both showing its tumor-
suppressive activity. ARF has been shown to monitor potentially harmful oncogenic …
suppressive activity. ARF has been shown to monitor potentially harmful oncogenic …
Apoptosis induced by adenovirus-mediated p14ARF expression in U2OS osteosarcoma cells is associated with increased Fas expression
M Kim, M Sgagias, X Deng, YJ Jung, T Rikiyama… - Biochemical and …, 2004 - Elsevier
The INK4A/ARF locus on chromosome 9 is a tumor suppressor gene frequently mutated in
human cancers. In order to study the effects of p14ARF expression in tumor cells, we …
human cancers. In order to study the effects of p14ARF expression in tumor cells, we …
Human tumor suppressor p14ARF negatively regulates rRNA transcription and inhibits UBF1 transcription factor phosphorylation
O Ayrault, L Andrique, D Fauvin, B Eymin, S Gazzeri… - Oncogene, 2006 - nature.com
The nucleolar Arf protein has been shown to regulate cell cycle through both p53-dependent
and-independent pathways. In addition to the well-characterized Arf-mdm2-p53 pathway …
and-independent pathways. In addition to the well-characterized Arf-mdm2-p53 pathway …
Tumor suppression by Ink4a–Arf: progress and puzzles
SW Lowe, CJ Sherr - Current opinion in genetics & development, 2003 - Elsevier
The two products of the Ink4a–Arf locus, p16Ink4a and p19Arf (p14ARF in humans), are
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
potent tumor suppressors that regulate the activities of the retinoblastoma protein and the …
Growth suppression by a p14ARF exon 1β adenovirus in human tumor cell lines of varying p53 and Rb status
N Saadatmandi, T Tyler, Y Huang, A Haghighi… - Cancer gene …, 2002 - nature.com
We have analyzed the ability of an adenoviral vector encoding the exon 1β region of the p14
ARF tumor suppressor (ARF) to suppress the growth and viability of an array of tumor cell …
ARF tumor suppressor (ARF) to suppress the growth and viability of an array of tumor cell …
The ARF tumor suppressor: structure, functions and status in cancer
P Ozenne, B Eymin, E Brambilla… - International journal of …, 2010 - Wiley Online Library
Abstract The INK4b‐ARF‐INK4a locus encodes two members of the INK4 family of cyclin‐
dependent kinase inhibitors, p15INK4b and p16INK4a, and a completely unrelated protein …
dependent kinase inhibitors, p15INK4b and p16INK4a, and a completely unrelated protein …
Expression of p14ARF overcomes tumor resistance to p53
W Lu, J Lin, J Chen - Cancer research, 2002 - AACR
Tumors without p53 mutation are often resistant to p53 gene therapy. We examined the
mechanism using p53-resistant A549 cells and p53-sensitive H1299 cells. We found that …
mechanism using p53-resistant A549 cells and p53-sensitive H1299 cells. We found that …
Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function
T Kamijo, E van de Kamp, MJ Chong, F Zindy, JA Diehl… - Cancer research, 1999 - AACR
The alternative reading frame product (p19ARF) of the mouse INK4a/ARF locus is induced
by oncoproteins such as Myc and E1A as part of a checkpoint response that limits cell cycle …
by oncoproteins such as Myc and E1A as part of a checkpoint response that limits cell cycle …