p19ARF suppresses the growth of cells lacking p53 through an unknown mechanism.
p19ARF was found to complex with transcription factors E2F1,-2, and-3. Levels of …

The INK4a/ARF locus encodes two physically linked tumor suppressor proteins, p16INK4a
and ARF, which regulate the RB and p53 pathways, respectively. The unusual genomic …

Tumor suppressor proteins must be exquisitely regulated since they can induce cell death
while preventing cancer. For example, the p19 ARF tumor suppressor (p14 ARF in humans) …

p19ARF is a potent tumor suppressor. By inactivating Mdm2, p19ARF upregulates p53
activities to induce cell cycle arrest and sensitize cells to apoptosis in the presence of …

Mounting genetic evidence suggests that each product of the Ink4a/Arf locus, p16 INK4a and
p19 ARF, possesses tumor-suppressor activity (Kamijo et al., 1997; Krimpenfort et al., 2001; …

The mammalian ARF-INK4a locus uniquely encodes two cell cycle inhibitors by using
separate promoters and alternative reading frames. p16 INK4a maintains the retinoblastoma …

It is generally accepted that the ARF tumor suppressor induces p53-dependent growth arrest
by sequestering the p53 antagonist Mdm2 in the nucleolus. Previous mutagenic studies of …

The INK4a/ARF locus encodes two unrelated cell cycle-regulatory proteins that both function
in tumor suppression, p16INK4a and p14ARF. In human tumors including breast cancer …

Abstract P16 and P14ARF are two tumor suppressors encoded by the locus ink4a-arf which
is frequently deleted in human tumors. Recent experiments performed with mouse …

The human ARF/INK4a locus encodes two cell cycle inhibitors, p16INK4a and p14ARF, by
using separate promoters. A variety of mitogenic stimuli upregulate ARF but a direct …