Abstract p19ARF is induced in response to oncogene activation or during cellular
senescence in mouse embryo fibroblasts, triggering p53-dependent and p53-independent …

Tumor suppressor protein p19 ARF (Arf; p14 ARF in humans) functions in both p53-
dependent and-independent modes to counteract hyper-proliferative signals caused by …

The INK4a gene encodes two distinct growth inhibitors—the cyclin-dependent kinase
inhibitor p16 Ink4a, which is a component of the Rb pathway, and the tumor suppressor p19 …

Background: The p14ARF protein encoded by the INK4a/ARF locus promotes degradation
of the MDM2 protein and thus prevents the MDM2-mediated inhibition of p53. Homozygous …

The Ink4a/Arf locus encodes p16Ink4a and p19Arf and is among the most frequently
mutated tumor suppressor loci in human cancer. In mice, many of these effects appear to be …

The ARF tumor suppressor protects us against cancer through protein-protein interactionsin
partially defined p53-dependent and p53-independent pathways. We performed a two …

The cell-cycle regulatory gene INK4A-ARF (CDKN2A) has two alternative transcripts that
produce entirely different proteins, namely p14ARF and p16, which have complementary …

p53 acts as a potent tumor suppressor largely through its ability to induce cell death by
apoptosis. Diverse cellular stress conditions, eg, DNA damage, hypoxia, and oncogene …

Evidence is accumulating about the role of individual AP-1 components in cell proliferation
and transformation. Notably, Ras-mediated transformation is characterized by the …

ARF encodes a potent tumor suppressor that antagonizes MDM2, a negative regulator of
p53. ARF also suppresses the proliferation of cells lacking p53, and loss of ARF in p53-null …