The cyclin-dependent kinase inhibitor p16INK4a encoded by the INK4A/CDKN2A/MTS1
gene is a frequent target of 9p21 inactivation in human lung cancers. The p14ARF transcript …

The INK4a/ARF locus on human chromosome 9p resides at the nexus of two critical cell
cycle regulatory pathways, the p53 pathway and the retinoblastoma (pRb) gene pathway …

Abstract p14/p19ARF (ARF) is a tumor suppressor gene that is frequently mutated in human
cancer. ARF has multiple tumor suppressor functions, some of which are mediated by …

The INK4A locus encodes two independent but overlapping genes, p16 INK4A and p19
ARF, and is frequently inactivated in human cancers. The unusual structure of this locus has …

Background The tumor suppressors p14ARF (ARF) and p16INK4A (p16) are encoded by
overlapping reading frames at the CDKN2A/INK4A locus on chromosome 9p21. In human …

Deletion of the INK4a/ARF locus at 9p21 is detected with high frequency in human
melanoma. Within a short genomic distance, this locus encodes several proteins with …

Inactivation of the p53 pathway represents the most common molecular defect of human
cancer. But in the setting of melanoma, a highly aggressive and invariably fatal malignancy …

p14ARF, the alternative product from the human INK4a/ARF locus, antagonizes Hdm2 and
mediates p53 activation in response to oncogenic stimuli. An immunohistochemical study of …

In tumorigenesis of the skin, activated Ras co-operates with mutations that inactivate the
tumour suppressor p53, but the molecular basis for this co-operation remains unresolved …

The INK4a locus encodes two structurally unrelated tumor suppressor proteins, p16 INK4a
and p14 ARF. Although the former is one of the most common targets for inactivation in …