Activation of ARF by oncogenic stress in mouse fibroblasts is independent of E2F1 and E2F2
I Palmero, M Murga, A Zubiaga, M Serrano - Oncogene, 2002 - nature.com
The ARF tumour suppressor protein (p14 ARF in human and p19 ARF in mouse) is a major
mediator of the activation of p53 in response to oncogenic stress. Little is known about the …
mediator of the activation of p53 in response to oncogenic stress. Little is known about the …
Ink4‐Arf locus in cancer and aging
CJ Sherr - Wiley Interdisciplinary Reviews: Developmental …, 2012 - Wiley Online Library
Three tumor suppressor genes at the small (< 50 kb) INK4‐ARF (CDKN2A/B) locus on
human chromosome 9p21 coordinate a signaling network that depends on the activities of …
human chromosome 9p21 coordinate a signaling network that depends on the activities of …
Regulation of p14ARF through subnuclear compartmentalization
RA Gjerset, K Bandyopadhyay - Cell Cycle, 2006 - Taylor & Francis
The p53-mediated pathway cell cycle arrest and apoptosis is central to cancer and an
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …
important point of focus for therapeutics development. The p14ARF (" ARF") tumor …
A functional link between the tumour suppressors ARF and p33ING1
The ARF tumour suppressor protein plays a critical role in the activation of p53 in response
to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2 …
to oncogenic stress. ARF can activate p53 through nucleolar sequestration of Mdm2 …
Human ARF protein interacts with topoisomerase I and stimulates its activity
The ARF gene (p19 ARF in mouse and p14 ARF in man) has become a central actor of the
cell cycle regulation process as it participates to the ARF-MDM2-p53 pathway and the Rb …
cell cycle regulation process as it participates to the ARF-MDM2-p53 pathway and the Rb …
The ARF-B23 connection: implications for growth control and cancer treatment
Y Zhang - Cell Cycle, 2004 - Taylor & Francis
The tumor suppressor ARF induces a p53-dependent and-independent cell cycle arrest.
Unlike nucleoplasmic localized MDM2 and p53, ARF localizes in the nucleolus. The role of …
Unlike nucleoplasmic localized MDM2 and p53, ARF localizes in the nucleolus. The role of …
ARF promotes accumulation of retinoblastoma protein through inhibition of MDM2
DLF Chang, W Qiu, H Ying, Y Zhang, CY Chen… - Oncogene, 2007 - nature.com
The INK4a/ARF locus, encoding two tumor suppressor proteins, p16 INK4a and p14 ARF
(ARF), plays key roles in many cellular processes including cell proliferation, apoptosis …
(ARF), plays key roles in many cellular processes including cell proliferation, apoptosis …
p19ARF directly and differentially controls the functions of c-Myc independently of p53
Y Qi, MA Gregory, Z Li, JP Brousal, K West, SR Hann - Nature, 2004 - nature.com
Increased expression of the oncogenic transcription factor c-Myc causes unregulated cell
cycle progression. c-Myc can also cause apoptosis, but it is not known whether the activation …
cycle progression. c-Myc can also cause apoptosis, but it is not known whether the activation …
ARF the Integrator: Linking NF-? B, p53 and Checkpoint Kinases
S Rocha, ND Perkins - Cell Cycle, 2005 - Taylor & Francis
The ARF tumour suppressor initiates the cellular response to aberrant oncogeneactivation
through binding to and inhibiting the activity of Hdm2/Mdm2, the inhibitor ofp53. However …
through binding to and inhibiting the activity of Hdm2/Mdm2, the inhibitor ofp53. However …
Alterations of p14ARF, p53, and p73 Genes Involved in the E2F-1-mediated Apoptotic Pathways in Non-Small Cell Lung Carcinoma
SA Nicholson, NT Okby, MA Khan, JA Welsh… - Cancer research, 2001 - AACR
Overexpression of E2F-1 induces apoptosis by both a p14 ARF-p53-and a p73-mediated
pathway. p14 ARF is the alternate tumor suppressor product of the INK4a/ARF locus that is …
pathway. p14 ARF is the alternate tumor suppressor product of the INK4a/ARF locus that is …