[HTML][HTML] New tools for immunologists: models of lymph node function from cells to tissues
T Ozulumba, AN Montalbine… - Frontiers in …, 2023 - frontiersin.org
The lymph node is a highly structured organ that mediates the body's adaptive immune
response to antigens and other foreign particles. Central to its function is the distinct spatial …
response to antigens and other foreign particles. Central to its function is the distinct spatial …
The lymph node at a glance–how spatial organization optimizes the immune response
SM Grant, M Lou, L Yao, RN Germain… - Journal of Cell …, 2020 - journals.biologists.com
ABSTRACT A hallmark of the mammalian immune system is its ability to respond efficiently
to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore …
to foreign antigens without eliciting an inappropriate response to self-antigens. Furthermore …
Same yet different—how lymph node heterogeneity affects immune responses
P Cruz de Casas, K Knöpper, R Dey Sarkar… - Nature Reviews …, 2024 - nature.com
Lymph nodes are secondary lymphoid organs in which immune responses of the adaptive
immune system are initiated and regulated. Distributed throughout the body and embedded …
immune system are initiated and regulated. Distributed throughout the body and embedded …
Systems biology approaches for understanding cellular mechanisms of immunity in lymph nodes during infection
HP Mirsky, MJ Miller, JJ Linderman… - Journal of theoretical …, 2011 - Elsevier
Adaptive immunity is initiated in secondary lymphoid tissues when naive T cells recognize
foreign antigen presented as MHC-bound peptide on the surface of dendritic cells. Only a …
foreign antigen presented as MHC-bound peptide on the surface of dendritic cells. Only a …
Acute lymph node slices are a functional model system to study immunity ex vivo
MC Belanger, AG Ball, MA Catterton… - ACS pharmacology & …, 2021 - ACS Publications
The lymph node is a highly organized and dynamic structure that is critical for facilitating the
intercellular interactions that constitute adaptive immunity. Most ex vivo studies of the lymph …
intercellular interactions that constitute adaptive immunity. Most ex vivo studies of the lymph …
[PDF][PDF] Illuminating the landscape of in vivo immunity: insights from dynamic in situ imaging of secondary lymphoid tissues
A central feature of the immune system is the migratory behavior of its cellular components.
Thus, fully understanding the generation and maintenance of immune responses must …
Thus, fully understanding the generation and maintenance of immune responses must …
[PDF][PDF] The biophysics of lymphatic transport: engineering tools and immunological consequences
Lymphatic vessels mediate fluid flows that affect antigen distribution and delivery, lymph
node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here …
node stromal remodeling, and cell-cell interactions, to thus regulate immune activation. Here …
Lymph node stroma dynamics and approaches for their visualization
R Gentek, M Bajénoff - Trends in immunology, 2017 - cell.com
Lymphoid stromal cells are best known as the architectural cells of lymphoid organs. For
decades, they have been considered as inert elements of the immune system but this view …
decades, they have been considered as inert elements of the immune system but this view …
Predicting lymph node output efficiency using systems biology
Dendritic cells (DCs) capture pathogens and foreign antigen (Ag) in peripheral tissues and
migrate to secondary lymphoid tissues, such as lymph nodes (LNs), where they present …
migrate to secondary lymphoid tissues, such as lymph nodes (LNs), where they present …
A stochastic view of lymphocyte motility and trafficking within the lymph node
SH Wei, I Parker, MJ Miller… - Immunological reviews, 2003 - Wiley Online Library
Two‐photon microscopy is providing literal insight into the cellular dynamics of lymphoid
organs and, guided by analysis of three‐dimensional images, into mechanisms that underlie …
organs and, guided by analysis of three‐dimensional images, into mechanisms that underlie …