The cells of the immune system respond to a great variety of different signals that frequently
reach them simultaneously. Computational models of signaling pathways and cellular …

Secondary lymphoid organs (SLO), such as lymph nodes and the spleen, display a complex
micro-architecture. In the T cell zone the micro-architecture is provided by a network of …

Fibroblastic reticular cells (FRCs) form a road-like cellular network in lymph nodes (LNs) that
provides essential chemotactic, survival, and regulatory signals for immune cells. While the …

Deep tissue imaging has become state of the art in biology, but now the problem is to
quantify spatial information in a global, organ‐wide context. Although access to the raw data …

The lymphatic system consists of a unidirectional hierarchy of vessels responsible for fluid
homeostasis, lipid absorption, and the transport of immune cells and antigens to secondary …

The lymphatic system is responsible for controlling tissue fluid pressure by facilitating flow of
lymph (ie the plasma and cells that enter the lymphatic system). Because lymph contains …

The conduit network is a hallmark of lymph node microanatomy, but lack of suitable imaging
technology has prevented comprehensive investigation of its topology. We employed an …

Successful immune responses depend on the spatiotemporal coordination of immune cell
migration, interactions, and effector functions in lymphoid and parenchymal tissues. Real …

The single-cell revolution is paving the way towards the molecular characterisation of every
cell type in the human body, revealing relationships between cell types and states at high …

Reactive lymph nodes (LNs) are sites where pMHC-loaded dendritic cells (DCs) interact
with rare cognate T cells, leading to their clonal expansion. While DC interactions with T cell …