Lymphatic contractile dysfunction is central to a number of pathologies that affect millions of
people worldwide. Due to its critical role in the process of inflammation, a dysfunctional …

Lymphocytes are highly mobile cells that travel throughout the body in response to a
tremendous variety of stimuli. Revealing lymphocyte trafficking patterns in vivo is necessary …

Although lymphocytes are one of the most symmetrical cells, they receive their activating
signals directionally, in the sense that these signals come from cell–cell contact, almost …

Immune responses are regulated by diffusible mediators, the cytokines, which act at sub-
nanomolar concentrations. The spatial range of cytokine communication is a crucial, yet …

Lymphoid organs are meeting zones where lymphocytes come together and encounter
antigens present in the blood and lymph or as delivered by cells migrating from the draining …

Secondary lymphoid organs like lymph nodes (LN s) are the main inductive sites for
adaptive immune responses. Lymphocytes are constantly entering LN s, scanning the …

The lymphoid tissues are characterized by a complex organized architecture that is
supported by a network of stromal cells. These stromal cells play many important roles in …

The frequent observation of organized lymphoid structures that resemble secondary
lymphoid organs in tissues that are targeted by chronic inflammatory processes, such as …

Recently developed approaches for highly multiplexed imaging have revealed complex
patterns of cellular positioning and cell-cell interactions with important roles in both cellular …

Following immunization, lymph nodes dynamically expand and contract. The mechanical
and cellular changes enabling the early-stage expansion of lymph nodes have been …