Mounting a protective immune response is critically dependent on the orchestrated
movement of cells within lymphoid tissues. The structure of secondary lymphoid organs …

The formerly distinct fields of lymphocyte signal transduction and cytoskeletal remodeling
have recently become linked, as proteins involved in transducing signals downstream of …

The adaptive immune response is initiated in lymph nodes by contact between antigen-
bearing dendritic cells (DCs) and antigen-specific T cells. A selected number of naïve T cells …

How is the amoeboid movement of lymphocytes in secondary lymphoid organs
orchestrated? In this issue of Immunity, Bajénoff et al.(2006) demonstrate that stromal cell …

There is a need for better predictive models of the human immune system to evaluate safety
and efficacy of immunomodulatory drugs and biologics for successful product development …

A key to understanding the functioning of the immune system is to define the mechanisms
that facilitate directed lymphocyte migration to and within tissues. The recent development of …

Highlights•The dynamic spatial behavior of T cells is essential to their protective
function.•Novel imaging techniques enable visualization of T cell migration and cellular …

Generating adaptive immunity after infection or immunization requires physical interactions
within a lymph node (LN) T-zone between antigen-bearing dendritic cells (DCs) that arrive …

Background Moving from the molecular and cellular level to a multi-scale systems
understanding of immune responses requires the development of novel approaches to …

Lymphatic and blood vessels are formed by specialized lymphatic endothelial cells (LEC)
and blood endothelial cells (BEC), respectively. These endothelial populations not only form …