Genetic architecture of left ventricular noncompaction in adults

SB Ross, ES Singer, E Driscoll, N Nowak… - Human genome …, 2020 - nature.com
The genetic etiology and heritability of left ventricular noncompaction (LVNC) in adults is
unclear. This study sought to assess the value of genetic testing in adults with LVNC. Adults …

Clinical and genetic complexities of left ventricular noncompaction: preventing overdiagnosis in a disease we do not understand

SB Ross, C Semsarian - JAMA cardiology, 2018 - jamanetwork.com
The Existing Evidence Traditionally, LVNC has been diagnosed according to criteria applied
to transthoracic echocardiogram results, which focus on the ratio of noncompacted to …

Genetic spectrum of left ventricular non-compaction in paediatric patients

T Vershinina, Y Fomicheva, A Muravyev, J Jorholt… - Cardiology, 2020 - karger.com
Introduction: Left ventricular non-compaction (LVNC) represents a genetically
heterogeneous cardiomyopathy which occurs in both children and adults. Its genetic …

Novel genetic triggers and genotype–phenotype correlations in patients with left ventricular noncompaction

K Miszalski-Jamka, JL Jefferies, W Mazur… - Circulation …, 2017 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) is a genetically and phenotypically
heterogeneous disease and, although increasingly recognized in clinical practice, there is a …

Targeted panel sequencing in adult patients with left ventricular non‐compaction reveals a large genetic heterogeneity

P Richard, F Ader, M Roux, E Donal, JC Eicher… - Clinical …, 2019 - Wiley Online Library
Left ventricular non‐compaction (LVNC) is a cardiomyopathy that may be of genetic origin;
however, few data are available about the yield of mutation, the spectrum of genes and …

The importance of genetic counseling, DNA diagnostics, and cardiologic family screening in left ventricular noncompaction cardiomyopathy

YM Hoedemaekers, K Caliskan, M Michels… - Circulation …, 2010 - Am Heart Assoc
Background—Left ventricular (LV) noncompaction (LVNC) is a distinct cardiomyopathy
featuring a thickened bilayered LV wall consisting of a thick endocardial layer with …

Genetic testing in pediatric left ventricular noncompaction

EM Miller, RB Hinton, R Czosek, A Lorts… - Circulation …, 2017 - Am Heart Assoc
Background—Left ventricular noncompaction (LVNC) can occur in isolation or can co-occur
with a cardiomyopathy phenotype or cardiovascular malformation. The yield of …

Genetic basis of left ventricular noncompaction

P Rojanasopondist, L Nesheiwat… - Circulation: Genomic …, 2022 - Am Heart Assoc
Background: Left ventricular noncompaction (LVNC) is the third most common pediatric
cardiomyopathy characterized by a thinned myocardium and prominent trabeculations. Next …

A wide and specific spectrum of genetic variants and genotype–phenotype correlations revealed by next‐generation sequencing in patients with left ventricular …

C Wang, Y Hata, K Hirono, A Takasaki… - Journal of the …, 2017 - Am Heart Assoc
Background Left ventricular noncompaction (LVNC) has since been classified as a primary
genetic cardiomyopathy, but the genetic basis is not fully evaluated. The aim of the present …

Is left ventricular noncompaction a trait, phenotype, or disease? The evidence points to phenotype

RE Hershberger, A Morales… - Circulation: Cardiovascular …, 2017 - Am Heart Assoc
2 Hershberger et al Left Ventricular Noncompaction 1480 individuals from the UK-Canadian
TASCFORCE study (Tayside Screening for Cardiac Events), also identified LVNC as a …